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1977 1
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1,640 results

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Page 1
Showing results for protein frederic
Search for Protin Frédéric instead (1 results)
Mechanisms and pathology of protein misfolding and aggregation.
Louros N, Schymkowitz J, Rousseau F. Louros N, et al. Nat Rev Mol Cell Biol. 2023 Dec;24(12):912-933. doi: 10.1038/s41580-023-00647-2. Epub 2023 Sep 8. Nat Rev Mol Cell Biol. 2023. PMID: 37684425 Review.
Despite advances in machine learning-based protein structure prediction, we are still far from fully understanding how proteins fold into their native conformation. ...Here, we review the current understanding of how intrinsic protein conformational propensit …
Despite advances in machine learning-based protein structure prediction, we are still far from fully understanding how proteins …
The Biology of Huntingtin.
Saudou F, Humbert S. Saudou F, et al. Neuron. 2016 Mar 2;89(5):910-26. doi: 10.1016/j.neuron.2016.02.003. Neuron. 2016. PMID: 26938440 Free article. Review.
Huntingtin (HTT) is now a famous protein because an abnormal expansion of a glutamine stretch (polyQ) in its N-terminal sequence leads to the devastating neurodegenerative disorder Huntington's disease (HD). ...Notwithstanding with the value of this approach, evidence has …
Huntingtin (HTT) is now a famous protein because an abnormal expansion of a glutamine stretch (polyQ) in its N-terminal sequence lead …
Protein structure and aggregation: a marriage of necessity ruled by aggregation gatekeepers.
Houben B, Rousseau F, Schymkowitz J. Houben B, et al. Trends Biochem Sci. 2022 Mar;47(3):194-205. doi: 10.1016/j.tibs.2021.08.010. Epub 2021 Sep 22. Trends Biochem Sci. 2022. PMID: 34561149 Review.
Protein aggregation propensity is a pervasive and seemingly inescapable property of proteomes. Strikingly, a significant fraction of the proteome is supersaturated, meaning that, for these proteins, their native conformation is less stable than the aggregated state. …
Protein aggregation propensity is a pervasive and seemingly inescapable property of proteomes. Strikingly, a significant fraction of …
DNA-encoded library-enabled discovery of proximity-inducing small molecules.
Mason JW, Chow YT, Hudson L, Tutter A, Michaud G, Westphal MV, Shu W, Ma X, Tan ZY, Coley CW, Clemons PA, Bonazzi S, Berst F, Briner K, Liu S, Zécri FJ, Schreiber SL. Mason JW, et al. Nat Chem Biol. 2024 Feb;20(2):170-179. doi: 10.1038/s41589-023-01458-4. Epub 2023 Nov 2. Nat Chem Biol. 2024. PMID: 37919549
Small molecules that induce protein-protein associations represent powerful tools to modulate cell circuitry. We sought to develop a platform for the direct discovery of compounds able to induce association of any two preselected proteins, using the E3 ligase …
Small molecules that induce protein-protein associations represent powerful tools to modulate cell circuitry. We sought to dev …
Early-onset autoimmunity associated with SOCS1 haploinsufficiency.
Hadjadj J, Castro CN, Tusseau M, Stolzenberg MC, Mazerolles F, Aladjidi N, Armstrong M, Ashrafian H, Cutcutache I, Ebetsberger-Dachs G, Elliott KS, Durieu I, Fabien N, Fusaro M, Heeg M, Schmitt Y, Bras M, Knight JC, Lega JC, Lesca G, Mathieu AL, Moreews M, Moreira B, Nosbaum A, Page M, Picard C, Ronan Leahy T, Rouvet I, Ryan E, Sanlaville D, Schwarz K, Skelton A, Viallard JF, Viel S, Villard M, Callebaut I, Picard C, Walzer T, Ehl S, Fischer A, Neven B, Belot A, Rieux-Laucat F. Hadjadj J, et al. Nat Commun. 2020 Oct 21;11(1):5341. doi: 10.1038/s41467-020-18925-4. Nat Commun. 2020. PMID: 33087723 Free PMC article.
Here, by whole-exome/genome sequencing we identify heterozygous, autosomal-dominant, germline loss-of-function mutations in the SOCS1 gene in ten patients from five unrelated families with early onset autoimmune manifestations. The intracellular protein SOCS1 is known to d …
Here, by whole-exome/genome sequencing we identify heterozygous, autosomal-dominant, germline loss-of-function mutations in the SOCS1 gene i …
[Biomarker, what is the pathologist's role?].
Bibeau F. Bibeau F. Ann Pathol. 2019 Jun;39(3):177-178. doi: 10.1016/j.annpat.2019.05.002. Ann Pathol. 2019. PMID: 31160017 French. No abstract available.
Nuance Matters.
Stiefel F, Bourquin C. Stiefel F, et al. J Thorac Oncol. 2019 Jan;14(1):e15. doi: 10.1016/j.jtho.2018.08.2037. J Thorac Oncol. 2019. PMID: 30579549 Free article. No abstract available.
Mechanical stimuli control liver homeostasis.
Lemaigre FP. Lemaigre FP. J Hepatol. 2019 Jul;71(1):12-13. doi: 10.1016/j.jhep.2019.04.002. Epub 2019 Apr 26. J Hepatol. 2019. PMID: 31036351 No abstract available.
TGFβ Signaling in the Tumor Microenvironment.
Goulet CR, Pouliot F. Goulet CR, et al. Adv Exp Med Biol. 2021;1270:89-105. doi: 10.1007/978-3-030-47189-7_6. Adv Exp Med Biol. 2021. PMID: 33123995 Review.
Multiscale Dynamic Structuring of Bacterial Chromosomes.
Lioy VS, Junier I, Boccard F. Lioy VS, et al. Annu Rev Microbiol. 2021 Oct 8;75:541-561. doi: 10.1146/annurev-micro-033021-113232. Epub 2021 Aug 3. Annu Rev Microbiol. 2021. PMID: 34343019 Review.
1,640 results