Multitracer PET/CT with [¹⁸F]Fluorodeoxiglucose and [¹⁸F]Fluorocholine in the Initial Staging of Multiple Myeloma Patients Applying the IMPeTus Criteria: A Pilot Study

Initial staging of patients diagnosed with multiple myeloma (MM) can lead to negative results using conventional diagnostic imaging workup, including [¹⁸F]Fluorodesoxiglucose ([¹⁸F]FDG) PET/CT. The aim of this prospective pilot study was to evaluate the diagnostic efficacy of [¹⁸F]Fluorocholine ([¹⁸F]FCH) PET/CT in the initial staging of MM patients who were candidates for autologous bone marrow transplant. Materials and Methods: The inclusion criteria of our study were: (a) patients diagnosed with MM; (b) candidates for autologous bone marrow transplant (AT); and (c) studied with [¹⁸F]FCH PET/CT and [¹⁸F]FDG PET/CT for initial staging less than 4 weeks apart. Imaging analysis included the presence of: bone marrow infiltration, focal bone lesions, and para-medullary or extra-medullary disease, according to the proposed IMPeTus criteria. The analysis was performed per lesion, per patient, and per location. Results: The study population included ten patients. Globally, [¹⁸F]FCH PET/CT showed bone marrow uptake in all the patients and visualised 16 more focal lesions than [¹⁸F]FDG PET/CT. One patient presented a plasmacytoma, detected by both tracers. Extra-medullary and para-medullary disease was identified with different degrees of uptake by both tracers. In summary, [¹⁸F]FCH PET seemed to be superior to [¹⁸F]FDG PET/CT in detecting focal bone lesions. SUVmax values were slightly higher in [¹⁸F]FCH PET/CT than in [¹⁸F]FDG PET/CT. Conclusions: Taking into account the small study population, according to our results, [¹⁸F]FCH PET/CT could be a useful tool for staging MM patients.