Aglacins A-D, first representatives of a new class of aryltetralin cyclic ether lignans from Aglaia cordata

B G Wang; R Ebel; B W Nugroho; D Prijono; W Frank; K G Steube; X J Hao; P Proksch

doi:10.1021/np0102962

Aglacins A-D, first representatives of a new class of aryltetralin cyclic ether lignans from Aglaia cordata

J Nat Prod. 2001 Dec;64(12):1521-6. doi: 10.1021/np0102962.

Authors

B G Wang¹, R Ebel, B W Nugroho, D Prijono, W Frank, K G Steube, X J Hao, P Proksch

Affiliation

¹ Institut für Pharmazeutische Biologie, Heinrich-Heine-Universität Düsseldorf, Universitätsstrasse 1, Geb. 26.23, D-40225 Düsseldorf, Germany.

PMID: 11754603
DOI: 10.1021/np0102962

Abstract

Four new metabolites, aglacins A-D (1-4), were identified from the methanol extract of the stem bark of Aglaia cordata. These compounds represent a new class of aryltetralin cyclic ether lignan. The structure of aglacin A (1) including the absolute configuration was elucidated by interpretation of spectral data, X-ray crystal structure determination, and employing the modified Mosher's method. In addition, three other derivatives, aglacins B-D (2-4), were isolated and identified by spectral means.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Chromatography, High Pressure Liquid
Crystallography, X-Ray
Drug Screening Assays, Antitumor
Ethers, Cyclic / chemistry
Ethers, Cyclic / isolation & purification*
HL-60 Cells / drug effects
Humans
Indonesia
Lignans / chemistry
Lignans / isolation & purification*
Meliaceae / chemistry*
Molecular Conformation
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Plant Bark / chemistry
Plant Stems / chemistry
Plants, Medicinal / chemistry*
Stereoisomerism
Tumor Cells, Cultured / drug effects

Substances

Ethers, Cyclic
Lignans