Pathogenic Autoimmunity in Atherosclerosis Evolves From Initially Protective Apolipoprotein B(100)-Reactive CD4(+) T-Regulatory Cells.
Wolf D, Gerhardt T, Winkels H, Michel NA, Pramod AB, Ghosheh Y, Brunel S, Buscher K, Miller J, McArdle S, Baas L, Kobiyama K, Vassallo M, Ehinger E, Dileepan T, Ali A, Schell M, Mikulski Z, Sidler D, Kimura T, Sheng X, Horstmann H, Hansen S, Mitre LS, Stachon P, Hilgendorf I, Gaddis DE, Hedrick C, Benedict CA, Peters B, Zirlik A, Sette A, Ley K.
Wolf D, et al.
Circulation. 2020 Sep 29;142(13):1279-1293. doi: 10.1161/CIRCULATIONAHA.119.042863. Epub 2020 Jul 24.
Circulation. 2020.
PMID: 32703007
Free PMC article.
Clinical data suggest the existence of apoB-specific CD4(+) T cells with an atheroprotective, regulatory T cell (T(reg)) phenotype in healthy individuals. ...In single-cell RNA sequencing, apoB(+) T cells formed several clusters with mixed T(H) …
Clinical data suggest the existence of apoB-specific CD4(+) T cells with an atheroprotective, regulatory T cell (T(reg) …