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2023 | 4 |
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Page 1
Dual allosteric and orthosteric pharmacology of synthetic analog cannabidiol-dimethylheptyl, but not cannabidiol, on the cannabinoid CB2 receptor.
Biochem Pharmacol. 2023 Dec;218:115924. doi: 10.1016/j.bcp.2023.115924. Epub 2023 Nov 14.
Biochem Pharmacol. 2023.
PMID: 37972874
Free article.
Multicomponent Reaction-Assisted Drug Discovery: A Time- and Cost-Effective Green Approach Speeding Up Identification and Optimization of Anticancer Drugs.
Graziano G, Stefanachi A, Contino M, Prieto-Díaz R, Ligresti A, Kumar P, Scilimati A, Sotelo E, Leonetti F.
Graziano G, et al. Among authors: kumar p.
Int J Mol Sci. 2023 Apr 1;24(7):6581. doi: 10.3390/ijms24076581.
Int J Mol Sci. 2023.
PMID: 37047554
Free PMC article.
Review.
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Systematic Modification of the Substitution Pattern of the 7-Hydroxy-5-oxopyrazolo[4,3-b]pyridine-6-carboxamide Scaffold Enabled the Discovery of New Ligands with High Affinity and Selectivity for the Cannabinoid Type 2 Receptor.
Mugnaini C, Kostrzewa M, Casini M, Kumar P, Catallo V, Allarà M, Guastaferro L, Brizzi A, Paolino M, Tafi A, Kapatais C, Giorgi G, Vacondio F, Mor M, Corelli F, Ligresti A.
Mugnaini C, et al. Among authors: kumar p.
Molecules. 2023 Jun 24;28(13):4958. doi: 10.3390/molecules28134958.
Molecules. 2023.
PMID: 37446625
Free PMC article.
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N-[1,3-Dialkyl(aryl)-2-oxoimidazolidin-4-ylidene]-aryl(alkyl)sulphonamides as Novel Selective Human Cannabinoid Type 2 Receptor (hCB2R) Ligands; Insights into the Mechanism of Receptor Activation/Deactivation.
Gianquinto E, Sodano F, Rolando B, Kostrzewa M, Allarà M, Mahmoud AM, Kumar P, Spyrakis F, Ligresti A, Chegaev K.
Gianquinto E, et al. Among authors: kumar p.
Molecules. 2022 Nov 23;27(23):8152. doi: 10.3390/molecules27238152.
Molecules. 2022.
PMID: 36500256
Free PMC article.
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Motifs in Natural Products as Useful Scaffolds to Obtain Novel Benzo[d]imidazole-Based Cannabinoid Type 2 (CB2) Receptor Agonists.
Cho AYH, Chung H, Romero-Parra J, Kumar P, Allarà M, Ligresti A, Gallardo-Garrido C, Pessoa-Mahana H, Faúndez M, Pessoa-Mahana CD.
Cho AYH, et al. Among authors: kumar p.
Int J Mol Sci. 2023 Jun 30;24(13):10918. doi: 10.3390/ijms241310918.
Int J Mol Sci. 2023.
PMID: 37446093
Free PMC article.
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Novel pyrrole based CB2 agonists: New insights on CB2 receptor role in regulating neurotransmitters' tone.
Di Micco S, Ciaglia T, Salviati E, Michela P, Kostrzewa M, Musella S, Schiano Moriello A, Di Sarno V, Smaldone G, Di Matteo F, Capolupo I, Infantino R, Bifulco G, Pepe G, Sommella EM, Kumar P, Basilicata MG, Allarà M, Sánchez-Fernández N, Aso E, Gomez-Monterrey IM, Campiglia P, Ostacolo C, Maione S, Ligresti A, Bertamino A.
Di Micco S, et al. Among authors: kumar p.
Eur J Med Chem. 2024 Apr 5;269:116298. doi: 10.1016/j.ejmech.2024.116298. Epub 2024 Mar 11.
Eur J Med Chem. 2024.
PMID: 38493727
Free article.
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Novel Dual-Acting Hybrids Targeting Type-2 Cannabinoid Receptors and Cholinesterase Activity Show Neuroprotective Effects In Vitro and Amelioration of Cognitive Impairment In Vivo.
Mugnaini C, Brizzi A, Paolino M, Scarselli E, Castelli R, de Candia M, Gambacorta N, Nicolotti O, Kostrzewa M, Kumar P, Mahmoud AM, Borgonetti V, Iannotta M, Morace A, Galeotti N, Maione S, Altomare CD, Ligresti A, Corelli F.
Mugnaini C, et al. Among authors: kumar p.
ACS Chem Neurosci. 2024 Mar 6;15(5):955-971. doi: 10.1021/acschemneuro.3c00656. Epub 2024 Feb 19.
ACS Chem Neurosci. 2024.
PMID: 38372253
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