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Systematic Modification of the Substitution Pattern of the 7-Hydroxy-5-oxopyrazolo[4,3-b]pyridine-6-carboxamide Scaffold Enabled the Discovery of New Ligands with High Affinity and Selectivity for the Cannabinoid Type 2 Receptor.
Mugnaini C, Kostrzewa M, Casini M, Kumar P, Catallo V, Allarà M, Guastaferro L, Brizzi A, Paolino M, Tafi A, Kapatais C, Giorgi G, Vacondio F, Mor M, Corelli F, Ligresti A. Mugnaini C, et al. Among authors: kumar p. Molecules. 2023 Jun 24;28(13):4958. doi: 10.3390/molecules28134958. Molecules. 2023. PMID: 37446625 Free PMC article.
N-[1,3-Dialkyl(aryl)-2-oxoimidazolidin-4-ylidene]-aryl(alkyl)sulphonamides as Novel Selective Human Cannabinoid Type 2 Receptor (hCB2R) Ligands; Insights into the Mechanism of Receptor Activation/Deactivation.
Gianquinto E, Sodano F, Rolando B, Kostrzewa M, Allarà M, Mahmoud AM, Kumar P, Spyrakis F, Ligresti A, Chegaev K. Gianquinto E, et al. Among authors: kumar p. Molecules. 2022 Nov 23;27(23):8152. doi: 10.3390/molecules27238152. Molecules. 2022. PMID: 36500256 Free PMC article.
Novel pyrrole based CB2 agonists: New insights on CB2 receptor role in regulating neurotransmitters' tone.
Di Micco S, Ciaglia T, Salviati E, Michela P, Kostrzewa M, Musella S, Schiano Moriello A, Di Sarno V, Smaldone G, Di Matteo F, Capolupo I, Infantino R, Bifulco G, Pepe G, Sommella EM, Kumar P, Basilicata MG, Allarà M, Sánchez-Fernández N, Aso E, Gomez-Monterrey IM, Campiglia P, Ostacolo C, Maione S, Ligresti A, Bertamino A. Di Micco S, et al. Among authors: kumar p. Eur J Med Chem. 2024 Apr 5;269:116298. doi: 10.1016/j.ejmech.2024.116298. Epub 2024 Mar 11. Eur J Med Chem. 2024. PMID: 38493727 Free article.
Novel Dual-Acting Hybrids Targeting Type-2 Cannabinoid Receptors and Cholinesterase Activity Show Neuroprotective Effects In Vitro and Amelioration of Cognitive Impairment In Vivo.
Mugnaini C, Brizzi A, Paolino M, Scarselli E, Castelli R, de Candia M, Gambacorta N, Nicolotti O, Kostrzewa M, Kumar P, Mahmoud AM, Borgonetti V, Iannotta M, Morace A, Galeotti N, Maione S, Altomare CD, Ligresti A, Corelli F. Mugnaini C, et al. Among authors: kumar p. ACS Chem Neurosci. 2024 Mar 6;15(5):955-971. doi: 10.1021/acschemneuro.3c00656. Epub 2024 Feb 19. ACS Chem Neurosci. 2024. PMID: 38372253