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Strategies for In Vivo Screening and Mitigation of Hepatotoxicity Associated with Antisense Drugs.
Kamola PJ, Maratou K, Wilson PA, Rush K, Mullaney T, McKevitt T, Evans P, Ridings J, Chowdhury P, Roulois A, Fairchild A, McCawley S, Cartwright K, Gooderham NJ, Gant TW, Moores K, Hughes SA, Edbrooke MR, Clark K, Parry JD. Kamola PJ, et al. Mol Ther Nucleic Acids. 2017 Sep 15;8:383-394. doi: 10.1016/j.omtn.2017.07.003. Epub 2017 Jul 8. Mol Ther Nucleic Acids. 2017. PMID: 28918038 Free PMC article.
We propose that a combination of in silico OTE predictions, streamlined in vivo hepatotoxicity screening, and a transcriptome-wide selectivity screen is a valid approach to identifying and progressing safer compounds....
We propose that a combination of in silico OTE predictions, streamlined in vivo hepatotoxicity screening, and a transcriptome-wide selectivi …
Gallbladder Radiation Protection in SIRT-Quantitative Anatomical Study of Hepatic Vasculature.
Piasecki P, Brzozowski K, Ziecina P, Wierzbicki M, Budzynska A, Mazurek A, Dziuk M, Maciak M, Iller E, Narloch J. Piasecki P, et al. J Clin Med. 2019 Sep 24;8(10):1531. doi: 10.3390/jcm8101531. J Clin Med. 2019. PMID: 31554288 Free PMC article.
Conclusions: Leaking in (99m)Tc-MAA ((99m)Tc - labelled macroaggregated albumin) was related to the presence of additional arteries. Regardless of cystic artery embolization, it is 2.5 times safer to inject microspheres distal to its origin, compared to proximal injection. …
Conclusions: Leaking in (99m)Tc-MAA ((99m)Tc - labelled macroaggregated albumin) was related to the presence of additional arteries. Regardl …
Extrabronchial symptoms and late phase reaction enhance the diagnostic value of aspirin bronchial challenge.
Tworek D, Zielińska-Wyderkiewicz E, Górski P, Kuna P. Tworek D, et al. Postepy Dermatol Alergol. 2015 Dec;32(6):431-6. doi: 10.5114/pdia.2015.56098. Epub 2015 Dec 11. Postepy Dermatol Alergol. 2015. PMID: 26755906 Free PMC article.
INTRODUCTION: Lysine aspirin (l-ASA) bronchial challenge can be used in the diagnostics of aspirin exacerbated respiratory disease. It is safer than oral challenge, however it is characterized by a lower sensitivity. ...
INTRODUCTION: Lysine aspirin (l-ASA) bronchial challenge can be used in the diagnostics of aspirin exacerbated respiratory disease. It is …