Abstract
Recent studies focusing on identifying the biological agents of Catharsius molossus have led to the identification of three new N-acetyldopamine dimers molossusamide A-C (1-3) and two known compounds 4 and 5. The structures of the new compounds were identified by comprehensive spectroscopic evidences. Compound 4 was found to have inhibitory effects towards COX-1 and COX-2.
Keywords:
COX-1; COX-2; Catharsius molossus; N-acetyldopamine dimers.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cell Line
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Coleoptera / chemistry
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Coleoptera / metabolism*
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Cyclooxygenase 1 / metabolism*
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Cyclooxygenase 2 / metabolism*
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Dogs
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Dopamine / analogs & derivatives*
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Dopamine / chemistry
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Dopamine / pharmacology
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Enzyme Inhibitors / pharmacology*
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HeLa Cells
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Humans
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Insect Proteins / chemistry
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Insect Proteins / pharmacology
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MCF-7 Cells
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Madin Darby Canine Kidney Cells
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Molecular Structure
Substances
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Enzyme Inhibitors
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Insect Proteins
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N-acetyldopamine
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Cyclooxygenase 1
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Cyclooxygenase 2
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Dopamine