Identification of N-Acetyldopamine Dimers from the Dung Beetle Catharsius molossus and Their COX-1 and COX-2 Inhibitory Activities

Molecules. 2015 Aug 27;20(9):15589-96. doi: 10.3390/molecules200915589.

Abstract

Recent studies focusing on identifying the biological agents of Catharsius molossus have led to the identification of three new N-acetyldopamine dimers molossusamide A-C (1-3) and two known compounds 4 and 5. The structures of the new compounds were identified by comprehensive spectroscopic evidences. Compound 4 was found to have inhibitory effects towards COX-1 and COX-2.

Keywords: COX-1; COX-2; Catharsius molossus; N-acetyldopamine dimers.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line
  • Coleoptera / chemistry
  • Coleoptera / metabolism*
  • Cyclooxygenase 1 / metabolism*
  • Cyclooxygenase 2 / metabolism*
  • Dogs
  • Dopamine / analogs & derivatives*
  • Dopamine / chemistry
  • Dopamine / pharmacology
  • Enzyme Inhibitors / pharmacology*
  • HeLa Cells
  • Humans
  • Insect Proteins / chemistry
  • Insect Proteins / pharmacology
  • MCF-7 Cells
  • Madin Darby Canine Kidney Cells
  • Molecular Structure

Substances

  • Enzyme Inhibitors
  • Insect Proteins
  • N-acetyldopamine
  • Cyclooxygenase 1
  • Cyclooxygenase 2
  • Dopamine