Enhanced amphotericin B production by genetically engineered Streptomyces nodosus.
Huang K, Zhang B, Shen ZY, Cai X, Liu ZQ, Zheng YG.
Huang K, et al.
Microbiol Res. 2021 Jan;242:126623. doi: 10.1016/j.micres.2020.126623. Epub 2020 Oct 13.
Microbiol Res. 2021.
PMID: 33189073
Free article.
The deletion of the PKS5 gene led to the titer of AmB improved from 5.01 g/L to 6.32 g/L while the by-product amphotericin A (AmA) reduced from 0.51 g/L to 0.12 g/L. A sequence of genes including PKS amphA, acc1, mme and mcm were overexpressed in a deltaPKS5 mutant, result …
The deletion of the PKS5 gene led to the titer of AmB improved from 5.01 g/L to 6.32 g/L while the by-product amphotericin A (AmA) reduced f …