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Nanoparticle-induced neuronal toxicity across placental barriers is mediated by autophagy and dependent on astrocytes.
Hawkins SJ, Crompton LA, Sood A, Saunders M, Boyle NT, Buckley A, Minogue AM, McComish SF, Jiménez-Moreno N, Cordero-Llana O, Stathakos P, Gilmore CE, Kelly S, Lane JD, Case CP, Caldwell MA. Hawkins SJ, et al. Among authors: stathakos p. Nat Nanotechnol. 2018 May;13(5):427-433. doi: 10.1038/s41565-018-0085-3. Epub 2018 Apr 2. Nat Nanotechnol. 2018. PMID: 29610530
In-vivo evidence that high mobility group box 1 exerts deleterious effects in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model and Parkinson's disease which can be attenuated by glycyrrhizin.
Santoro M, Maetzler W, Stathakos P, Martin HL, Hobert MA, Rattay TW, Gasser T, Forrester JV, Berg D, Tracey KJ, Riedel G, Teismann P. Santoro M, et al. Among authors: stathakos p. Neurobiol Dis. 2016 Jul;91:59-68. doi: 10.1016/j.nbd.2016.02.018. Epub 2016 Feb 24. Neurobiol Dis. 2016. PMID: 26921471 Free PMC article.