A Click Chemistry Approach towards Flavin-Cyclodextrin Conjugates-Bioinspired Sulfoxidation Catalysts

Petra Tomanová; Jiří Šturala; Miloš Buděšínský; Radek Cibulka

doi:10.3390/molecules201119667

A Click Chemistry Approach towards Flavin-Cyclodextrin Conjugates-Bioinspired Sulfoxidation Catalysts

Molecules. 2015 Nov 4;20(11):19837-48. doi: 10.3390/molecules201119667.

Authors

Petra Tomanová¹, Jiří Šturala², Miloš Buděšínský³, Radek Cibulka⁴

Affiliations

¹ Department of Organic Chemistry, University of Chemistry and Technology, Prague, Technická 5, 166 28 Prague 6, Czech Republic. peta.tomanova@gmail.com.
² Department of Organic Chemistry, University of Chemistry and Technology, Prague, Technická 5, 166 28 Prague 6, Czech Republic. sturalaj@vscht.cz.
³ Institute of Organic Chemistry and Biochemistry AS CR, v.v.i., Flemingovo nám. 2, 166 10 Prague 6, Czech Republic. budes@uochb.cas.cz.
⁴ Department of Organic Chemistry, University of Chemistry and Technology, Prague, Technická 5, 166 28 Prague 6, Czech Republic. cibulkar@vscht.cz.

Abstract

A click chemistry approach based on the reaction between alkynylflavins and mono(6-azido-6-deoxy)-β-cyclodextrin has proven to be a useful tool for the synthesis of flavin-cyclodextrin conjugates studied as monooxygenase mimics in enantioselective sulfoxidations.

Keywords: click chemistry; cyclodextrin; flavin; green chemistry; monooxygenase; oxidation; sulfoxides.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Catalysis
Click Chemistry*
Cyclodextrins / chemistry*
Flavins / chemistry*
Green Chemistry Technology
Sulfoxides / chemistry*

Substances

Cyclodextrins
Flavins
Sulfoxides