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Page 1
BCL-2 Inhibitor ABT-737 Effectively Targets Leukemia-Initiating Cells with Differential Regulation of Relevant Genes Leading to Extended Survival in a NRAS/BCL-2 Mouse Model of High Risk-Myelodysplastic Syndrome.
Int J Mol Sci. 2021 Sep 30;22(19):10658. doi: 10.3390/ijms221910658.
Int J Mol Sci. 2021.
PMID: 34638998
Free PMC article.
The proneural gene ASCL1 governs the transcriptional subgroup affiliation in glioblastoma stem cells by directly repressing the mesenchymal gene NDRG1.
Narayanan A, Gagliardi F, Gallotti AL, Mazzoleni S, Cominelli M, Fagnocchi L, Pala M, Piras IS, Zordan P, Moretta N, Tratta E, Brugnara G, Altabella L, Bozzuto G, Gorombei P, Molinari A, Padua RA, Bulfone A, Politi LS, Falini A, Castellano A, Mortini P, Zippo A, Poliani PL, Galli R.
Narayanan A, et al. Among authors: gorombei p.
Cell Death Differ. 2019 Sep;26(9):1813-1831. doi: 10.1038/s41418-018-0248-7. Epub 2018 Dec 11.
Cell Death Differ. 2019.
PMID: 30538287
Free PMC article.
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DNA-mediated adjuvant immunotherapy extends survival in two different mouse models of myeloid malignancies.
Le Pogam C, Patel S, Gorombei P, Guerenne L, Krief P, Omidvar N, Tekin N, Bernasconi E, Sicre F, Schlageter MH, Chopin M, Noguera ME, West R, Abu A, Mathews V, Pla M, Fenaux P, Chomienne C, Padua RA.
Le Pogam C, et al. Among authors: gorombei p.
Oncotarget. 2015 Oct 20;6(32):32494-508. doi: 10.18632/oncotarget.5572.
Oncotarget. 2015.
PMID: 26378812
Free PMC article.
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GEP analysis validates high risk MDS and acute myeloid leukemia post MDS mice models and highlights novel dysregulated pathways.
Guerenne L, Beurlet S, Said M, Gorombei P, Le Pogam C, Guidez F, de la Grange P, Omidvar N, Vanneaux V, Mills K, Mufti GJ, Sarda-Mantel L, Noguera ME, Pla M, Fenaux P, Padua RA, Chomienne C, Krief P.
Guerenne L, et al. Among authors: gorombei p.
J Hematol Oncol. 2016 Jan 27;9:5. doi: 10.1186/s13045-016-0235-8.
J Hematol Oncol. 2016.
PMID: 26817437
Free PMC article.
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BCL-2 inhibition with ABT-737 prolongs survival in an NRAS/BCL-2 mouse model of AML by targeting primitive LSK and progenitor cells.
Beurlet S, Omidvar N, Gorombei P, Krief P, Le Pogam C, Setterblad N, de la Grange P, Leboeuf C, Janin A, Noguera ME, Hervatin F, Sarda-Mantel L, Konopleva M, Andreeff M, Tu AW, Fan AC, Felsher DW, Whetton A, Pla M, West R, Fenaux P, Chomienne C, Padua RA.
Beurlet S, et al. Among authors: gorombei p.
Blood. 2013 Oct 17;122(16):2864-76. doi: 10.1182/blood-2012-07-445635. Epub 2013 Aug 13.
Blood. 2013.
PMID: 23943652
Free PMC article.
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