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Chlorotoxin binds to both matrix metalloproteinase 2 and neuropilin 1.
Farkas S, Cioca D, Murányi J, Hornyák P, Brunyánszki A, Szekér P, Boros E, Horváth P, Hujber Z, Rácz GZ, Nagy N, Tóth R, Nyitray L, Péterfi Z. Farkas S, et al. Among authors: hornyak p. J Biol Chem. 2023 Sep;299(9):104998. doi: 10.1016/j.jbc.2023.104998. Epub 2023 Jun 30. J Biol Chem. 2023. PMID: 37394009 Free PMC article.
XRCC1 mutation is associated with PARP1 hyperactivation and cerebellar ataxia.
Hoch NC, Hanzlikova H, Rulten SL, Tétreault M, Komulainen E, Ju L, Hornyak P, Zeng Z, Gittens W, Rey SA, Staras K, Mancini GM, McKinnon PJ, Wang ZQ, Wagner JD; Care4Rare Canada Consortium; Yoon G, Caldecott KW. Hoch NC, et al. Among authors: hornyak p. Nature. 2017 Jan 5;541(7635):87-91. doi: 10.1038/nature20790. Epub 2016 Dec 21. Nature. 2017. PMID: 28002403 Free PMC article.
14-3-3 proteins activate Pseudomonas exotoxins-S and -T by chaperoning a hydrophobic surface.
Karlberg T, Hornyak P, Pinto AF, Milanova S, Ebrahimi M, Lindberg M, Püllen N, Nordström A, Löverli E, Caraballo R, Wong EV, Näreoja K, Thorsell AG, Elofsson M, De La Cruz EM, Björkegren C, Schüler H. Karlberg T, et al. Among authors: hornyak p. Nat Commun. 2018 Sep 17;9(1):3785. doi: 10.1038/s41467-018-06194-1. Nat Commun. 2018. PMID: 30224724 Free PMC article.
KcsA-Kv1.x chimeras with complete ligand-binding sites provide improved predictivity for screening selective Kv1.x blockers.
Szekér P, Bodó T, Klima K, Csóti Á, Hanh NN, Murányi J, Hajdara A, Szántó TG, Panyi G, Megyeri M, Péterfi Z, Farkas S, Gyöngyösi N, Hornyák P. Szekér P, et al. Among authors: hornyak p. J Biol Chem. 2024 Apr;300(4):107155. doi: 10.1016/j.jbc.2024.107155. Epub 2024 Mar 11. J Biol Chem. 2024. PMID: 38479597 Free PMC article.
Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2.
Hornyak P, Askwith T, Walker S, Komulainen E, Paradowski M, Pennicott LE, Bartlett EJ, Brissett NC, Raoof A, Watson M, Jordan AM, Ogilvie DJ, Ward SE, Atack JR, Pearl LH, Caldecott KW, Oliver AW. Hornyak P, et al. Biochem J. 2016 Jul 1;473(13):1869-79. doi: 10.1042/BCJ20160180. Epub 2016 Apr 20. Biochem J. 2016. PMID: 27099339 Free PMC article.