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Estimation of SARS-CoV-2 Infection Fatality Rate by Age and Comorbidity Status Using Antibody Screening of Blood Donors During the COVID-19 Epidemic in Denmark.
Kaspersen KA, Hindhede L, Boldsen JK, Mikkelsen S, Vestergaard LS, Berthelsen AN, Moustsen-Helms IR, Holm DK, Nilsson AC, Sækmose SG, Sørensen E, Harritshøj LH, Aagaard B, Hjalgrim H, Lillevang ST, Jørgensen CS, Krause TG, Ullum H, Pedersen OBV, Ostrowski SR, Erikstrup C. Kaspersen KA, et al. J Infect Dis. 2022 Jan 18;225(2):219-228. doi: 10.1093/infdis/jiab566. J Infect Dis. 2022. PMID: 34788834 Free PMC article.
The IFR was low for people <51 years without comorbidity during the 2 waves (combined IFR=3.36 per 100000 infections). The IFR was below 3 for people aged 61-69 years without comorbidity. ...
The IFR was low for people <51 years without comorbidity during the 2 waves (combined IFR=3.36 per 100000 infections). The IFR was …
Investigating the inflammation marker neutrophil-to-lymphocyte ratio in Danish blood donors with restless legs syndrome.
Dowsett J, Didriksen M, Larsen MH, Dinh KM, Kaspersen KA, Mikkelsen S, Thørner LW, Sørensen E, Erikstrup C, Pedersen OB, Eugen-Olsen J, Banasik K, Ostrowski SR. Dowsett J, et al. PLoS One. 2021 Nov 12;16(11):e0259681. doi: 10.1371/journal.pone.0259681. eCollection 2021. PLoS One. 2021. PMID: 34767616 Free PMC article.
In an unadjusted logistic regression model, increased NLR was associated with RLS (OR = 1.10 per NLR unit increase [95%CI:1.01-1.20]; P = 0.032); however, the association was not significant in multivariate models adjusting for sex and age (P = 0.094) or sex, age, alcohol …
In an unadjusted logistic regression model, increased NLR was associated with RLS (OR = 1.10 per NLR unit increase [95%CI:1.01-1.20]; …
Seroprevalence and infection fatality rate of the SARS-CoV-2 Omicron variant in Denmark: A nationwide serosurveillance study.
Erikstrup C, Laksafoss AD, Gladov J, Kaspersen KA, Mikkelsen S, Hindhede L, Boldsen JK, Jørgensen SW, Ethelberg S, Holm DK, Bruun MT, Nissen J, Schwinn M, Brodersen T, Mikkelsen C, Sækmose SG, Sørensen E, Harritshøj LH, Aagaard B, Dinh KM, Busch MP, Jørgensen CS, Krause TG, Ullum H, Ostrowski SR, Espenhain L, Pedersen OBV. Erikstrup C, et al. Lancet Reg Health Eur. 2022 Oct;21:100479. doi: 10.1016/j.lanepe.2022.100479. Epub 2022 Aug 5. Lancet Reg Health Eur. 2022. PMID: 35959415 Free PMC article.
One third of infections were not captured by SARS-CoV-2 RT-PCR testing. The infection fatality rate (IFR) was 6.2 (CI: 5.1-7.5) per 100 000 infections. INTERPRETATION: Screening for anti-N IgG and linkage to national registers allowed us to detect recent infections and acc …
One third of infections were not captured by SARS-CoV-2 RT-PCR testing. The infection fatality rate (IFR) was 6.2 (CI: 5.1-7.5) per 1 …
High sequence similarity between avian pathogenic E. coli isolates from individual birds and within broiler chicken flocks during colibacillosis outbreaks.
Kravik IH, Kaspersen H, Sjurseth SK, Jonsson M, David B, Aspholm M, Sekse C. Kravik IH, et al. Vet Microbiol. 2022 Apr;267:109378. doi: 10.1016/j.vetmic.2022.109378. Epub 2022 Feb 19. Vet Microbiol. 2022. PMID: 35276620
Each flock was represented by five animals, showing typical lesions of colibacillosis, and spleen, liver and one other organ from each animal was sampled for APEC. A total of 47 E. coli isolates, one per organ, and approximately 15 isolates per flock were whole geno …
Each flock was represented by five animals, showing typical lesions of colibacillosis, and spleen, liver and one other organ from each anima …
Day-by-day symptoms following positive and negative PCR tests for SARS-CoV-2 in non-hospitalized healthcare workers: A 90-day follow-up study.
Nielsen KJ, Vestergaard JM, Schlünssen V, Bonde JP, Kaspersen KA, Biering K, Carstensen O, Greve T, Hansen KK, Dalbøge A, Flachs EM, Jespersen S, Hansen ML, Mikkelsen S, Thomsen MK, Redder JD, Würtz ET, Østergaard L, Erikstrup C, Kolstad HA. Nielsen KJ, et al. Int J Infect Dis. 2021 Jul;108:382-390. doi: 10.1016/j.ijid.2021.05.032. Epub 2021 May 20. Int J Infect Dis. 2021. PMID: 34022336 Free PMC article.
Their daily reported COVID-19-related symptoms were compared graphically and by logistic regression. RESULTS: Thirty per cent of the positive-test and close to 0% of the negative-test participants reported a reduced sense of taste and smell during all 90 days (adjusted odd …
Their daily reported COVID-19-related symptoms were compared graphically and by logistic regression. RESULTS: Thirty per cent of the …
Changes in General Practitioners' consultation frequency over time for patients with hypertension or anxiety/depression symptoms: a 10-year follow-up of the Norwegian HUNT study.
Skarshaug LJ, Kaspersen SL, Bjørngaard JH, Pape K. Skarshaug LJ, et al. Fam Pract. 2020 Mar 25;37(2):248-254. doi: 10.1093/fampra/cmz070. Fam Pract. 2020. PMID: 31690941
We registered GP consultations in 2007-16 and used general estimation equation models to estimate the level of GP consultations per month per year during follow-up. We used multilevel models with participants nested in their assigned regular GP to calculate GP-level …
We registered GP consultations in 2007-16 and used general estimation equation models to estimate the level of GP consultations per m …
Effects of extended-release niacin with laropiprant in high-risk patients.
HPS2-THRIVE Collaborative Group; Landray MJ, Haynes R, Hopewell JC, Parish S, Aung T, Tomson J, Wallendszus K, Craig M, Jiang L, Collins R, Armitage J. HPS2-THRIVE Collaborative Group, et al. N Engl J Med. 2014 Jul 17;371(3):203-12. doi: 10.1056/NEJMoa1300955. N Engl J Med. 2014. PMID: 25014686 Free article. Clinical Trial.
RESULTS: During a median follow-up period of 3.9 years, participants who were assigned to extended-release niacin-laropiprant had an LDL cholesterol level that was an average of 10 mg per deciliter (0.25 mmol per liter as measured in the central laboratory) lower an …
RESULTS: During a median follow-up period of 3.9 years, participants who were assigned to extended-release niacin-laropiprant had an LDL cho …
Glycolipid Biosurfactants Activate, Dimerize, and Stabilize Thermomyces lanuginosus Lipase in a pH-Dependent Fashion.
Madsen JK, Kaspersen JD, Andersen CB, Nedergaard Pedersen J, Andersen KK, Pedersen JS, Otzen DE. Madsen JK, et al. Biochemistry. 2017 Aug 15;56(32):4256-4268. doi: 10.1021/acs.biochem.7b00420. Epub 2017 Aug 7. Biochemistry. 2017. PMID: 28726390
Nevertheless, isothermal titration calorimetry reveals binding of only a few BS molecules per lipase. Size-exclusion chromatography and small-angle X-ray scattering suggest formation of TlL dimers with binding of small amounts of either RL or SL at the dimeric interface, f …
Nevertheless, isothermal titration calorimetry reveals binding of only a few BS molecules per lipase. Size-exclusion chromatography a …
Paroxetine-induced reduction of sexual incentive motivation in female rats is not modified by 5-HT1B or 5-HT2C antagonists.
Kaspersen H, Agmo A. Kaspersen H, et al. Psychopharmacology (Berl). 2012 Mar;220(2):269-80. doi: 10.1007/s00213-011-2475-1. Epub 2011 Sep 10. Psychopharmacology (Berl). 2012. PMID: 21909633
METHODS: Ovariectomized female rats were implanted with osmotic minipumps releasing 10 mg/kg per day of paroxetine or vehicle for 28 days. Tests for sexual incentive motivation and paced mating were performed just before implantation and at regular intervals thereafter. .. …
METHODS: Ovariectomized female rats were implanted with osmotic minipumps releasing 10 mg/kg per day of paroxetine or vehicle for 28 …
Transport infrastructure surveillance and monitoring by electromagnetic sensing: the ISTIMES project.
Proto M, Bavusi M, Bernini R, Bigagli L, Bost M, Bourquin F, Cottineau LM, Cuomo V, Della Vecchia P, Dolce M, Dumoulin J, Eppelbaum L, Fornaro G, Gustafsson M, Hugenschmidt J, Kaspersen P, Kim H, Lapenna V, Leggio M, Loperte A, Mazzetti P, Moroni C, Nativi S, Nordebo S, Pacini F, Palombo A, Pascucci S, Perrone A, Pignatti S, Ponzo FC, Rizzo E, Soldovieri F, Taillade F. Proto M, et al. Sensors (Basel). 2010;10(12):10620-39. doi: 10.3390/s101210620. Epub 2010 Nov 29. Sensors (Basel). 2010. PMID: 22163489 Free PMC article.