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Showing results for eisen cheng
Your search for Peisen Cheng retrieved no results
N6-Methyladenosine-modified circSAV1 triggers ferroptosis in COPD through recruiting YTHDF1 to facilitate the translation of IREB2.
Xia H, Wu Y, Zhao J, Cheng C, Lin J, Yang Y, Lu L, Xiang Q, Bian T, Liu Q. Xia H, et al. Cell Death Differ. 2023 May;30(5):1293-1304. doi: 10.1038/s41418-023-01138-9. Epub 2023 Feb 24. Cell Death Differ. 2023. PMID: 36828914 Free PMC article.
Mechanistically, m6A-modified circSAV1 formed an RNA-protein ternary complex of circSAV1/YTHDF1/IREB2 to facilitate the translation of IREB2 mRNA. Elevated protein levels of IREB2 disrupted iron homeostasis, resulting in accumulation of a labile iron pool (LIP) and …
Mechanistically, m6A-modified circSAV1 formed an RNA-protein ternary complex of circSAV1/YTHDF1/IREB2 to facilitate the translation of IREB2 …
Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms.
Billesbølle CB, Azumaya CM, Kretsch RC, Powers AS, Gonen S, Schneider S, Arvedson T, Dror RO, Cheng Y, Manglik A. Billesbølle CB, et al. Nature. 2020 Oct;586(7831):807-811. doi: 10.1038/s41586-020-2668-z. Epub 2020 Aug 19. Nature. 2020. PMID: 32814342 Free PMC article.
The serum level of iron in humans is tightly controlled by the action of the hormone hepcidin on the iron efflux transporter ferroportin. ...Aberrant ferroportin activity can lead to diseases of iron overload, such as haemochromatosis, or iron limitati …
The serum level of iron in humans is tightly controlled by the action of the hormone hepcidin on the iron efflux transporter f …
Swine influenza virus triggers ferroptosis in A549 cells to enhance virus replication.
Cheng J, Tao J, Li B, Shi Y, Liu H. Cheng J, et al. Virol J. 2022 Jun 17;19(1):104. doi: 10.1186/s12985-022-01825-y. Virol J. 2022. PMID: 35715835 Free PMC article.
Ferroptosis is a novel form of regulated cell death (RCD) that is mainly mediated by iron-dependent lipid peroxidation. Based on the proteomic data, we wondered whether IAV causes ferroptosis in host cells. ...In our experiment, aberrant expression of iron-binding p …
Ferroptosis is a novel form of regulated cell death (RCD) that is mainly mediated by iron-dependent lipid peroxidation. Based on the …
Artesunate alleviates liver fibrosis by regulating ferroptosis signaling pathway.
Kong Z, Liu R, Cheng Y. Kong Z, et al. Biomed Pharmacother. 2019 Jan;109:2043-2053. doi: 10.1016/j.biopha.2018.11.030. Epub 2018 Nov 26. Biomed Pharmacother. 2019. PMID: 30551460 Free article.
Moreover, primary HSCs isolated from different animal groups were cultured to detect biomarkers of ferroptosis including iron, lipid peroxidation, glutathione (GSH) and prostaglandin endoperoxide synthase 2 (ptgs2) levels. ...Furthermore, consistent with the experimental r …
Moreover, primary HSCs isolated from different animal groups were cultured to detect biomarkers of ferroptosis including iron, lipid …
Iron deposition-induced ferroptosis in alveolar type II cells promotes the development of pulmonary fibrosis.
Cheng H, Feng D, Li X, Gao L, Tang S, Liu W, Wu X, Yue S, Li C, Luo Z. Cheng H, et al. Biochim Biophys Acta Mol Basis Dis. 2021 Dec 1;1867(12):166204. doi: 10.1016/j.bbadis.2021.166204. Epub 2021 Jun 24. Biochim Biophys Acta Mol Basis Dis. 2021. PMID: 34175430 Free article.
Here, we investigated the role of ferroptosis in pulmonary fibrosis. We found a large amount of iron deposition in the lung tissue of patients with pulmonary fibrosis. We observed ferroptosis in alveolar type II (ATII) cells, fibrotic lung tissues of BLM-induced pulmonary …
Here, we investigated the role of ferroptosis in pulmonary fibrosis. We found a large amount of iron deposition in the lung tissue of …
Mitochondrial Regulation of Ferroptosis in Cancer Therapy.
Cheng X, Zhang J, Xiao Y, Wang Z, He J, Ke M, Liu S, Wang Q, Zhang L. Cheng X, et al. Int J Mol Sci. 2023 Jun 12;24(12):10037. doi: 10.3390/ijms241210037. Int J Mol Sci. 2023. PMID: 37373183 Free PMC article. Review.
Ferroptosis, characterized by glutamate overload, glutathione depletion, and cysteine/cystine deprivation during iron- and oxidative-damage-dependent cell death, is a particular mode of regulated cell death. ...
Ferroptosis, characterized by glutamate overload, glutathione depletion, and cysteine/cystine deprivation during iron- and oxidative- …
Mitochondrial iron metabolism and neurodegenerative diseases.
Cheng R, Dhorajia VV, Kim J, Kim Y. Cheng R, et al. Neurotoxicology. 2022 Jan;88:88-101. doi: 10.1016/j.neuro.2021.11.003. Epub 2021 Nov 5. Neurotoxicology. 2022. PMID: 34748789 Free PMC article. Review.
Iron is a key element for mitochondrial function and homeostasis, which is also crucial for maintaining the neuronal system, but too much iron promotes oxidative stress. ...Hence, the current review provides an update on the causal effects of iron overload in …
Iron is a key element for mitochondrial function and homeostasis, which is also crucial for maintaining the neuronal system, but too …
Thalassemia Intermedia: Chelator or Not?
Lee YC, Yen CT, Lee YL, Chen RJ. Lee YC, et al. Int J Mol Sci. 2022 Sep 5;23(17):10189. doi: 10.3390/ijms231710189. Int J Mol Sci. 2022. PMID: 36077584 Free PMC article. Review.
Iron overload is noted in TI due to the increasing iron absorption from the intestine. ...Liver iron concentration (LIC) 5 mg/g/dw measured by MRI and ferritin level > 300 ng/mL were suggested as indicators to start iron chelation therapy, and ir …
Iron overload is noted in TI due to the increasing iron absorption from the intestine. ...Liver iron concentration (LIC …
Iron and atrial fibrillation: A review.
Ju H, Liu T, Yang M, Cheng M, Wu G. Ju H, et al. Pacing Clin Electrophysiol. 2023 Apr;46(4):312-318. doi: 10.1111/pace.14678. Epub 2023 Mar 7. Pacing Clin Electrophysiol. 2023. PMID: 36799332 Review.
Interestingly, in AF patients with iron overload, interventions on iron metabolism, such as iron chelators and ferroptosis inhibitors, has been shown to prevent AF via reducing ferroptosis. Herein, we review the possible mechanisms, consequences, and therapeu …
Interestingly, in AF patients with iron overload, interventions on iron metabolism, such as iron chelators and ferropto …
FoxO1 regulates adipose transdifferentiation and iron influx by mediating Tgfbeta1 signaling pathway.
Shi L, Tao Z, Zheng L, Yang J, Hu X, Scott K, de Kloet A, Krause E, Collins JF, Cheng Z. Shi L, et al. Redox Biol. 2023 Jul;63:102727. doi: 10.1016/j.redox.2023.102727. Epub 2023 May 2. Redox Biol. 2023. PMID: 37156218 Free PMC article.
The browning phenotype in adO1KO mice was associated with an increased iron content in adipose tissue, concurrent with upregulation of proteins that facilitate iron uptake (DMT1 and TfR1) and iron import into mitochondria (Mfrn1). Analysis of hepatic and seru …
The browning phenotype in adO1KO mice was associated with an increased iron content in adipose tissue, concurrent with upregulation o …
2,769 results