New conjugated benzothiazole-N-oxides: synthesis and biological activity

Molecules. 2009 Dec 23;14(12):5382-8. doi: 10.3390/molecules14125382.

Abstract

Eleven new 2-styrylbenzothiazole-N-oxides have been prepared by aldol - type condensation reactions between 2-methylbenzothiazole-N-oxide and para-substituted benzaldehydes. Compounds with cyclic amino substituents showed typical push-pull molecule properties. Four compounds were tested against various bacterial strains as well as the protozoan Euglena gracilis as model microorganisms. Unlike previously prepared analogous benzothiazolium salts, only weak activity was recorded.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / chemical synthesis*
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology*
  • Antiprotozoal Agents / chemical synthesis*
  • Antiprotozoal Agents / chemistry
  • Antiprotozoal Agents / pharmacology*
  • Benzothiazoles / chemical synthesis*
  • Benzothiazoles / chemistry
  • Benzothiazoles / pharmacology*
  • Magnetic Resonance Spectroscopy
  • Microbial Sensitivity Tests
  • Quantitative Structure-Activity Relationship
  • Spectrophotometry, Ultraviolet

Substances

  • Anti-Bacterial Agents
  • Antiprotozoal Agents
  • Benzothiazoles