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Design, synthesis and cytotoxicity of the antitumor agent 1-azabicycles for chemoresistant glioblastoma cells.
Oliveira M, de Santana LLB, Serafim JC, Santos AO, Quintino MP, Correia JTM, Damasceno F, Sabino JR, Pires TRC, Coelho PLC, de Faria Lopes GP, Ulrich H, Costa SL, Cunha S. Oliveira M, et al. Among authors: coelho plc. Invest New Drugs. 2020 Oct;38(5):1257-1271. doi: 10.1007/s10637-019-00877-2. Epub 2019 Dec 14. Invest New Drugs. 2020. PMID: 31838735
Anti-inflammatory activity of Jatropha curcas L. in brain glial cells primary cultures.
Muniz Santana Bastos E, Bispo da Silva A, Cerqueira Coelho PL, Pereira Borges JM, Amaral da Silva VD, Moreau da Cunha VH, Costa SL. Muniz Santana Bastos E, et al. Among authors: cerqueira coelho pl. J Ethnopharmacol. 2021 Jan 10;264:113201. doi: 10.1016/j.jep.2020.113201. Epub 2020 Aug 16. J Ethnopharmacol. 2021. PMID: 32814081 Free article.
The flavonoid rutin and its aglycone quercetin modulate the microglia inflammatory profile improving antiglioma activity.
da Silva AB, Cerqueira Coelho PL, das Neves Oliveira M, Oliveira JL, Oliveira Amparo JA, da Silva KC, Soares JRP, Pitanga BPS, Dos Santos Souza C, de Faria Lopes GP, da Silva VDA, de Fátima Dias Costa M, Junier MP, Chneiweiss H, Moura-Neto V, Costa SL. da Silva AB, et al. Among authors: cerqueira coelho pl. Brain Behav Immun. 2020 Mar;85:170-185. doi: 10.1016/j.bbi.2019.05.003. Epub 2019 May 3. Brain Behav Immun. 2020. PMID: 31059805
Hedgehog pathway activation in oral squamous cell carcinoma: cancer-associated fibroblasts exhibit nuclear GLI-1 localization.
Guimaraes VSN, Vidal MTA, de Faro Valverde L, de Oliveira MG, de Oliveira Siquara da Rocha L, Coelho PLC, Soares FA, de Freitas Souza BS, Bezerra DP, Coletta RD, Pereira TA, Dos Santos JN, Gurgel Rocha CA. Guimaraes VSN, et al. Among authors: coelho plc. J Mol Histol. 2020 Dec;51(6):675-684. doi: 10.1007/s10735-020-09913-5. Epub 2020 Sep 30. J Mol Histol. 2020. PMID: 33000351
The flavonoid rutin modulates microglial/macrophage activation to a CD150/CD206 M2 phenotype.
Bispo da Silva A, Cerqueira Coelho PL, Alves Oliveira Amparo J, Alves de Almeida Carneiro MM, Pereira Borges JM, Dos Santos Souza C, Dias Costa MF, Mecha M, Guaza Rodriguez C, Amaral da Silva VD, Lima Costa S. Bispo da Silva A, et al. Among authors: cerqueira coelho pl. Chem Biol Interact. 2017 Aug 25;274:89-99. doi: 10.1016/j.cbi.2017.07.004. Epub 2017 Jul 8. Chem Biol Interact. 2017. PMID: 28693884
GANT61 Reduces Hedgehog Molecule (GLI1) Expression and Promotes Apoptosis in Metastatic Oral Squamous Cell Carcinoma Cells.
Bacelar Sacramento de Araújo T, de Oliveira Siquara da Rocha L, Torres Andion Vidal M, Cerqueira Coelho PL, Galvão Dos Reis M, Solano de Freitas Souza B, Botelho Pereira Soares M, Almeida Pereira T, Della Coletta R, Pereira Bezerra D, Borges Dias R, Araújo Gurgel Rocha C. Bacelar Sacramento de Araújo T, et al. Among authors: cerqueira coelho pl. Int J Mol Sci. 2020 Aug 24;21(17):6076. doi: 10.3390/ijms21176076. Int J Mol Sci. 2020. PMID: 32846867 Free PMC article.
The anti-hypertensive drug prazosin inhibits glioblastoma growth via the PKCδ-dependent inhibition of the AKT pathway.
Assad Kahn S, Costa SL, Gholamin S, Nitta RT, Dubois LG, Fève M, Zeniou M, Coelho PL, El-Habr E, Cadusseau J, Varlet P, Mitra SS, Devaux B, Kilhoffer MC, Cheshier SH, Moura-Neto V, Haiech J, Junier MP, Chneiweiss H. Assad Kahn S, et al. Among authors: coelho pl. EMBO Mol Med. 2016 May 2;8(5):511-26. doi: 10.15252/emmm.201505421. Print 2016 May. EMBO Mol Med. 2016. PMID: 27138566 Free PMC article.