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Page 1
Novel Skeletal Rearrangements of the Tigliane Diterpenoid Core.
Maioli C, Amin HIM, Chianese G, Minassi A, Reddell PW, Gaeta S, Taglialatela-Scafati O, Appendino G. Maioli C, et al. Among authors: reddell pw. J Nat Prod. 2023 Dec 22;86(12):2685-2690. doi: 10.1021/acs.jnatprod.3c00834. Epub 2023 Nov 22. J Nat Prod. 2023. PMID: 37991924 Free PMC article.
Activation of PKC supports the anticancer activity of tigilanol tiglate and related epoxytiglianes.
Cullen JK, Boyle GM, Yap PY, Elmlinger S, Simmons JL, Broit N, Johns J, Ferguson B, Maslovskaya LA, Savchenko AI, Mirzayans PM, Porzelle A, Bernhardt PV, Gordon VA, Reddell PW, Pagani A, Appendino G, Parsons PG, Williams CM. Cullen JK, et al. Among authors: reddell pw. Sci Rep. 2021 Jan 8;11(1):207. doi: 10.1038/s41598-020-80397-9. Sci Rep. 2021. PMID: 33420238 Free PMC article.
Tigilanol tiglate is an oncolytic small molecule that induces immunogenic cell death and enhances the response of both target and non-injected tumors to immune checkpoint blockade.
Cullen JK, Yap PY, Ferguson B, Bruce ZC, Koyama M, Handoko H, Hendrawan K, Simmons JL, Brooks KM, Johns J, Wilson ES, de Souza MMA, Broit N, Stewart P, Shelley D, McMahon T, Ogbourne SM, Nguyen TH, Lim YC, Pagani A, Appendino G, Gordon VA, Reddell PW, Boyle GM, Parsons PG. Cullen JK, et al. Among authors: reddell pw. J Immunother Cancer. 2024 Apr 24;12(4):e006602. doi: 10.1136/jitc-2022-006602. J Immunother Cancer. 2024. PMID: 38658031 Free PMC article.
20 results