Structure-based energetics of protein interfaces guides foot-and-mouth disease virus vaccine design.
Kotecha A, Seago J, Scott K, Burman A, Loureiro S, Ren J, Porta C, Ginn HM, Jackson T, Perez-Martin E, Siebert CA, Paul G, Huiskonen JT, Jones IM, Esnouf RM, Fry EE, Maree FF, Charleston B, Stuart DI.
Kotecha A, et al. Among authors: paul g.
Nat Struct Mol Biol. 2015 Oct;22(10):788-94. doi: 10.1038/nsmb.3096. Epub 2015 Sep 21.
Nat Struct Mol Biol. 2015.
PMID: 26389739
Free PMC article.
Here we devised a computational method to assess the relative stability of protein-protein interfaces and used it to design improved candidate vaccines for two poorly stable, but globally important, serotypes of FMDV: O and SAT2. We used a restrained molecular dynamics strategy t …
Here we devised a computational method to assess the relative stability of protein-protein interfaces and used it to design improved candida …