Abstract
This study investigated bioactive extracts of Polyalthia debilis (Annonaceae) with antimicrobial, antimalarial and cytotoxic activities. Extensive chromatographic isolations provided azafluorenone alkaloids; onychine (1) and 7-methoxyonychine (2) together with a mixture of beta-sitosterol and stigmasterol. The two alkaloids were isolated from the P. debilis for the first time. Isolated fractions containing a mixture of triterpenoids (C7, C8 and C9) exhibited the most potent antimicrobial activity against many bacterial strains with minimum inhibitory concentration of 64 microg/mL. Fractions with antimalarial and cytotoxic activities were also observed. The findings suggest the potential use of P. debilis in medicinal applications.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / adverse effects
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Alkaloids / chemistry*
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Alkaloids / pharmacology*
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Anti-Infective Agents / adverse effects
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Anti-Infective Agents / chemistry
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Anti-Infective Agents / pharmacology
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Antimalarials / adverse effects
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Antimalarials / chemistry
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Antimalarials / pharmacology
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Cell Line
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Cell Line, Tumor
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Cell Survival / drug effects
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Flavanones / chemistry
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Humans
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Microbial Sensitivity Tests
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Molecular Structure
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Plant Extracts / chemistry*
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Plant Extracts / pharmacology*
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Plasmodium falciparum / drug effects
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Polyalthia / chemistry*
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Pyridones / chemistry
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Sitosterols / chemistry
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Stigmasterol / chemistry
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Triterpenes / chemistry
Substances
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Alkaloids
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Anti-Infective Agents
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Antimalarials
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Flavanones
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Plant Extracts
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Pyridones
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Sitosterols
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Triterpenes
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onychine
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gamma-sitosterol
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Stigmasterol