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Verapamil inhibits TXNIP-NLRP3 inflammasome activation and preserves functional recovery after intracerebral hemorrhage in mice.
Ismael S, Patrick D, Salman M, Parveen A, Stanfill AG, Ishrat T. Ismael S, et al. Among authors: patrick d. Neurochem Int. 2022 Dec;161:105423. doi: 10.1016/j.neuint.2022.105423. Epub 2022 Oct 14. Neurochem Int. 2022. PMID: 36244583
ICH was induced by stereotactic injection of collagenase type VII (0.075 U) into the right striatum of adult male C57BL/6 mice. Verapamil (0.15 mg/kg) or saline was administered intravenously at 1 h post-ICH followed by oral (1 mg/kg/d) administration in drinking water for …
ICH was induced by stereotactic injection of collagenase type VII (0.075 U) into the right striatum of adult male C57BL/6 mice. Verapamil (0 …
Is the healthy middle ear a normally sterile site?
Westerberg BD, Kozak FK, Thomas EE, Blondel-Hill E, Brunstein JD, Patrick DM. Westerberg BD, et al. Among authors: patrick dm. Otol Neurotol. 2009 Feb;30(2):174-7. doi: 10.1097/MAO.0b013e31819225a0. Otol Neurotol. 2009. PMID: 19060773
OBJECTIVE: To systematically evaluate the presumption that the healthy middle ear becomes colonized with organisms via the patent eustachian tube using modern microbiologic techniques. STUDY DESIGN: Sterile saline washings were obtained from the middle ear of patients in a …
OBJECTIVE: To systematically evaluate the presumption that the healthy middle ear becomes colonized with organisms via the patent eustachian …
Megadose corticosteroid therapy following experimental traumatic spinal injury.
Faden AI, Jacobs TP, Patrick DH, Smith MT. Faden AI, et al. Among authors: patrick dh. J Neurosurg. 1984 Apr;60(4):712-7. doi: 10.3171/jns.1984.60.4.0712. J Neurosurg. 1984. PMID: 6707740
The authors have compared the effect of megadose dexamethasone and methylprednisolone therapy to that of saline treatment following traumatic cervical spinal injury in the cat. During 6 weeks postinjury, neurological recovery did not differ significantly in corticosteroid- …
The authors have compared the effect of megadose dexamethasone and methylprednisolone therapy to that of saline treatment following t …
Transforming growth factor alpha-Pseudomonas exotoxin fusion protein prolongs survival of nude mice bearing tumor xenografts.
Heimbrook DC, Stirdivant SM, Ahern JD, Balishin NL, Patrick DR, Edwards GM, Defeo-Jones D, FitzGerald DJ, Pastan I, Oliff A. Heimbrook DC, et al. Among authors: patrick dr. Proc Natl Acad Sci U S A. 1990 Jun;87(12):4697-701. doi: 10.1073/pnas.87.12.4697. Proc Natl Acad Sci U S A. 1990. PMID: 2352944 Free PMC article.
Animals were treated with a derivative of TGF alpha-PE40 in which the cysteine residues are replaced by alanine, termed "TGF alpha-PE40 delta cys," or with saline once a day for 5 days. Mice bearing EGFR+ tumor cells lived significantly (P less than 0.001) longer when trea …
Animals were treated with a derivative of TGF alpha-PE40 in which the cysteine residues are replaced by alanine, termed "TGF alpha-PE40 delt …
A comparison of diabetic foot ulcer patients managed in VHA and non-VHA settings.
Reiber GE, Smith DG, Carter J, Fotieo G, Deery HG 2nd, Sangeorzan JA, Lavery L, Pugh J, Peter-Riesch B, Assal JP, del Aguila M, Diehr P, Patrick DL, Boyko EJ. Reiber GE, et al. Among authors: patrick dl. J Rehabil Res Dev. 2001 May-Jun;38(3):309-17. J Rehabil Res Dev. 2001. PMID: 11440262 Free article.
Veterans received significantly fewer sharp debridements, total contact casts, and custom inserts than their nonveteran counterparts, and they had significantly more x-rays, local saline irrigations, IV antibiotics, and prescriptions for bed rest. ...
Veterans received significantly fewer sharp debridements, total contact casts, and custom inserts than their nonveteran counterparts, and th …