Fractional-order differentiation offers new degrees of freedom that simplify the design of high-performance dynamic controllers. The CRONE control system design (CSD) methodology proposes the design of robust controllers by using fractional-order operators. A software toolbox has been developed based on this methodology and is freely available for the international scientific and industrial communities. This paper presents both the CRONE CSD methodology and its implementation using the toolbox. The design of two robust controllers for irrigation canals shows how to use the toolbox.