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Antibody therapy in pancreatic cancer: mAb-ye we're onto something?
Boland AJ, O'Kane AA, Buick R, Longley DB, Scott CJ. Boland AJ, et al. Biochim Biophys Acta Rev Cancer. 2021 Aug;1876(1):188557. doi: 10.1016/j.bbcan.2021.188557. Epub 2021 May 1. Biochim Biophys Acta Rev Cancer. 2021. PMID: 33945846 Review.
Activation of innate-adaptive immune machinery by poly(I:C) exposes a therapeutic vulnerability to prevent relapse in stroma-rich colon cancer.
Corry SM, McCorry AM, Lannagan TR, Leonard NA, Fisher NC, Byrne RM, Tsantoulis P, Cortes-Lavaud X, Amirkhah R, Redmond KL, McCooey AJ, Malla SB, Rogan E, Sakhnevych S, Gillespie MA, White M, Richman SD, Jackstadt RF, Campbell AD, Maguire S; S:CORT and ACRCelerate consortia; McDade SS, Longley DB, Loughrey MB, Coleman HG, Kerr EM, Tejpar S, Maughan T, Leedham SJ, Small DM, Ryan AE, Sansom OJ, Lawler M, Dunne PD. Corry SM, et al. Gut. 2022 Dec;71(12):2502-2517. doi: 10.1136/gutjnl-2021-326183. Epub 2022 Apr 27. Gut. 2022. PMID: 35477539 Free PMC article.
Using in silico, in vitro and in vivo models, we demonstrate that the HPS is associated with antigen processing and presentation within discrete immune lineages in stroma-rich CC, downstream of double-stranded RNA and viral response signalling. Treatment with the TLR3 agonist pol …
Using in silico, in vitro and in vivo models, we demonstrate that the HPS is associated with antigen processing and presentation within disc …
The E3 ubiquitin ligase Itch regulates death receptor and cholesterol trafficking to affect TRAIL-mediated apoptosis.
Holloway J, Seeley A, Cobbe N, Turkington RC, Longley DB, Evergren E. Holloway J, et al. Cell Death Dis. 2024 Jan 12;15(1):40. doi: 10.1038/s41419-023-06417-4. Cell Death Dis. 2024. PMID: 38216558 Free PMC article.
We demonstrate that Itch knockdown cells are less sensitive to a Bcl-2 inhibitor, show impaired activation of Bax, cytochrome c release and an enhanced stability of the cholesterol transfer protein STARD1. ...An increase in STARD1 expression enhances cholesterol import to …
We demonstrate that Itch knockdown cells are less sensitive to a Bcl-2 inhibitor, show impaired activation of Bax, cytochrome c relea …
The pseudo-caspase FLIP(L) regulates cell fate following p53 activation.
Lees A, McIntyre AJ, Crawford NT, Falcone F, McCann C, Holohan C, Quinn GP, Roberts JZ, Sessler T, Gallagher PF, Gregg GMA, McAllister K, McLaughlin KM, Allen WL, Egan LJ, Ryan AE, Labonte-Wilson MJ, Dunne PD, Wappett M, Coyle VM, Johnston PG, Kerr EM, Longley DB, McDade SS. Lees A, et al. Proc Natl Acad Sci U S A. 2020 Jul 28;117(30):17808-17819. doi: 10.1073/pnas.2001520117. Epub 2020 Jul 13. Proc Natl Acad Sci U S A. 2020. PMID: 32661168 Free PMC article.
Clinical Positioning of the IAP Antagonist Tolinapant (ASTX660) in Colorectal Cancer.
Crawford N, Stott KJ, Sessler T, McCann C, McDaid W, Lees A, Latimer C, Fox JP, Munck JM, Smyth T, Shah A, Martins V, Lawler M, Dunne PD, Kerr EM, McDade SS, Coyle VM, Longley DB. Crawford N, et al. Mol Cancer Ther. 2021 Sep;20(9):1627-1639. doi: 10.1158/1535-7163.MCT-20-1050. Epub 2021 Aug 13. Mol Cancer Ther. 2021. PMID: 34389694 Free PMC article.
Functional Genomic Identification of Predictors of Sensitivity and Mechanisms of Resistance to Multivalent Second-Generation TRAIL-R2 Agonists.
Grinkevitch V, Wappett M, Crawford N, Price S, Lees A, McCann C, McAllister K, Prehn J, Young J, Bateson J, Gallagher L, Michaut M, Iyer V, Chatzipli A, Barthorpe S, Ciznadija D, Sloma I, Wesa A, Tice DA, Wessels L, Garnett M, Longley DB, McDermott U, McDade SS. Grinkevitch V, et al. Mol Cancer Ther. 2022 Apr 1;21(4):594-606. doi: 10.1158/1535-7163.MCT-21-0532. Mol Cancer Ther. 2022. PMID: 35086954 Free PMC article.
DR5-targeted, chemotherapeutic drug-loaded nanoparticles induce apoptosis and tumor regression in pancreatic cancer in vivo models.
Johnston MC, Nicoll JA, Redmond KM, Smyth P, Greene MK, McDaid WJ, Chan DKW, Crawford N, Stott KJ, Fox JP, Straubinger NL, Roche S, Clynes M, Straubinger RM, Longley DB, Scott CJ. Johnston MC, et al. J Control Release. 2020 Aug 10;324:610-619. doi: 10.1016/j.jconrel.2020.05.046. Epub 2020 Jun 3. J Control Release. 2020. PMID: 32504778 Free PMC article.
Controlled coupling of an ultrapotent auristatin warhead to cetuximab yields a next-generation antibody-drug conjugate for EGFR-targeted therapy of KRAS mutant pancreatic cancer.
Greene MK, Chen T, Robinson E, Straubinger NL, Minx C, Chan DKW, Wang J, Burrows JF, Van Schaeybroeck S, Baker JR, Caddick S, Longley DB, Mager DE, Straubinger RM, Chudasama V, Scott CJ. Greene MK, et al. Br J Cancer. 2020 Nov;123(10):1502-1512. doi: 10.1038/s41416-020-01046-6. Epub 2020 Sep 11. Br J Cancer. 2020. PMID: 32913288 Free PMC article.
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