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Protein Transduction Domain-Mediated Delivery of Recombinant Proteins and In Vitro Transcribed mRNAs for Protein Replacement Therapy of Human Severe Genetic Mitochondrial Disorders: The Case of Sco2 Deficiency.
Pharmaceutics. 2023 Jan 14;15(1):286. doi: 10.3390/pharmaceutics15010286.
Pharmaceutics. 2023.
PMID: 36678915
Free PMC article.
Review.
Intracellular delivery of full length recombinant human mitochondrial L-Sco2 protein into the mitochondria of permanent cell lines and SCO2 deficient patient's primary cells.
Foltopoulou PF, Tsiftsoglou AS, Bonovolias ID, Ingendoh AT, Papadopoulou LC.
Foltopoulou PF, et al.
Biochim Biophys Acta. 2010 Jun;1802(6):497-508. doi: 10.1016/j.bbadis.2010.02.009. Epub 2010 Mar 1.
Biochim Biophys Acta. 2010.
PMID: 20193760
Free article.
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Human recombinant mutated forms of the mitochondrial COX assembly Sco2 protein differ from wild-type in physical state and copper binding capacity.
Foltopoulou PF, Zachariadis GA, Politou AS, Tsiftsoglou AS, Papadopoulou LC.
Foltopoulou PF, et al.
Mol Genet Metab. 2004 Mar;81(3):225-36. doi: 10.1016/j.ymgme.2003.11.006.
Mol Genet Metab. 2004.
PMID: 14972329
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