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Page 1
Mechanism for antigenic peptide selection by endoplasmic reticulum aminopeptidase 1.
Giastas P, Mpakali A, Papakyriakou A, Lelis A, Kokkala P, Neu M, Rowland P, Liddle J, Georgiadis D, Stratikos E. Giastas P, et al. Among authors: kokkala p. Proc Natl Acad Sci U S A. 2019 Dec 26;116(52):26709-26716. doi: 10.1073/pnas.1912070116. Epub 2019 Dec 16. Proc Natl Acad Sci U S A. 2019. PMID: 31843903 Free PMC article.
Optimization and Structure-Activity Relationships of Phosphinic Pseudotripeptide Inhibitors of Aminopeptidases That Generate Antigenic Peptides.
Kokkala P, Mpakali A, Mauvais FX, Papakyriakou A, Daskalaki I, Petropoulou I, Kavvalou S, Papathanasopoulou M, Agrotis S, Fonsou TM, van Endert P, Stratikos E, Georgiadis D. Kokkala P, et al. J Med Chem. 2016 Oct 13;59(19):9107-9123. doi: 10.1021/acs.jmedchem.6b01031. Epub 2016 Sep 20. J Med Chem. 2016. PMID: 27606717
Editing the immunopeptidome of melanoma cells using a potent inhibitor of endoplasmic reticulum aminopeptidase 1 (ERAP1).
Koumantou D, Barnea E, Martin-Esteban A, Maben Z, Papakyriakou A, Mpakali A, Kokkala P, Pratsinis H, Georgiadis D, Stern LJ, Admon A, Stratikos E. Koumantou D, et al. Among authors: kokkala p. Cancer Immunol Immunother. 2019 Aug;68(8):1245-1261. doi: 10.1007/s00262-019-02358-0. Epub 2019 Jun 20. Cancer Immunol Immunother. 2019. PMID: 31222486 Free PMC article.
Rationally designed inhibitor targeting antigen-trimming aminopeptidases enhances antigen presentation and cytotoxic T-cell responses.
Zervoudi E, Saridakis E, Birtley JR, Seregin SS, Reeves E, Kokkala P, Aldhamen YA, Amalfitano A, Mavridis IM, James E, Georgiadis D, Stratikos E. Zervoudi E, et al. Among authors: kokkala p. Proc Natl Acad Sci U S A. 2013 Dec 3;110(49):19890-5. doi: 10.1073/pnas.1309781110. Epub 2013 Nov 18. Proc Natl Acad Sci U S A. 2013. PMID: 24248368 Free PMC article.