We report the fabrication and characterization of superconducting quantum interference devices (SQUIDs) based on InAs nanowires and vanadium superconducting electrodes. These mesoscopic devices are found to be extremely robust against thermal cycling and to operate up to temperatures of ∼ 2.5 K with reduced power dissipation. We show that our geometry allows one to obtain nearly-symmetric devices with very large magnetic field modulation of the critical current. All these properties make these devices attractive for sensitive magnetometry applications and quantum circuit implementation.