Is Adjunctive Hyperbaric Oxygen Treatment Alone or with Surgery the Proper Management for Active and Persistent Osteoradionecrosis?

Kamonwan Jenwitheesuk; Ajanee Mahakkanukrauh; Wiyada Punjaruk; Patravoot Vatanasapt; Kriangsak Jenwitheesuk; Palakorn Surakunprapha; Suthin Jinaporntham; Krittinant Uraiwan; Phasuk Limrattanapimpa

doi:10.1097/01.ASW.0000725164.18431.a7

Is Adjunctive Hyperbaric Oxygen Treatment Alone or with Surgery the Proper Management for Active and Persistent Osteoradionecrosis?

Adv Skin Wound Care. 2021 Feb 1;34(2):1-4. doi: 10.1097/01.ASW.0000725164.18431.a7.

Authors

Kamonwan Jenwitheesuk¹, Ajanee Mahakkanukrauh, Wiyada Punjaruk, Patravoot Vatanasapt, Kriangsak Jenwitheesuk, Palakorn Surakunprapha, Suthin Jinaporntham, Krittinant Uraiwan, Phasuk Limrattanapimpa

Affiliation

¹ At Khon Kaen University, Khon Kaen, Thailand, Kamonwan Jenwitheesuk, MD, is Associate Professor, Plastic & Reconstructive Unit, Department of Surgery, Faculty of Medicine; Ajanee Mahakkanukrauh, MD, is Associate Professor, Division of Allergy-Immunology-Rheumatology, Faculty of Medicine; Wiyada Punjaruk, MD, PhD, is Assistant Professor, Department of Physiology, Faculty of Medicine; Patravoot Vatanasapt, MD, is Assistant Professor, Head & Neck Surgery Unit, Department of Otorhinolaryngology, Faculty of Medicine; Kriangsak Jenwitheesuk, MD, is Associate Professor, General Surgery Unit, Department of Surgery, Faculty of Medicine; Palakorn Surakunprapha, MD, is Assistant Professor, Plastic & Reconstructive Unit, Department of Surgery, Faculty of Medicine; Suthin Jinaporntham, MD, DDS, is Assistant Professor, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry; Krittinant Uraiwan, DDS, is Maxillofacial Surgeon, Dental Department, Srinagarind Hospital, Faculty of Medicine; and Phasuk Limrattanapimpa, MNS, is Nurse Specialist, Hyperbaric Oxygen Therapy Unit, Srinagarind Hospital, Faculty of Medicine. Acknowledgments: The authors thank University of Wisconsin Professor Emeritus James A. Will for assistance with the English language presentation of the manuscript under the aegis of the Publication Clinic, Research Affairs, Faculty of Medicine, KKU. This study was funded by a grant from Khon Kaen University, Faculty of Medicine (no. MN61203). The authors have disclosed no other financial relationships related to this article. Submitted January 15, 2020; accepted in revised form March 4, 2020.

PMID: 33443917
DOI: 10.1097/01.ASW.0000725164.18431.a7

Abstract

This study enrolled patients with stage 3 osteoradionecrosis. There were three treatment modalities: antibiotics, hyperbaric oxygen therapy (HBOT), and surgery. Complete healing was the primary outcome. Multiple logistic regression analysis demonstrated that surgery with HBOT improved wound healing better than HBOT alone.

MeSH terms

Adult
Aged
Anti-Bacterial Agents / therapeutic use
Combined Modality Therapy
Female
Head and Neck Neoplasms / radiotherapy*
Humans
Hyperbaric Oxygenation*
Male
Mandibular Diseases / etiology
Mandibular Diseases / therapy*
Middle Aged
Osteoradionecrosis / etiology
Osteoradionecrosis / therapy*
Osteotomy
Plastic Surgery Procedures
Radiotherapy / adverse effects
Retrospective Studies
Thailand
Treatment Outcome
Wound Healing

Substances

Anti-Bacterial Agents