Deforestation/land-use changes are major drivers of regional climate change in central South America, impacting upon Amazonia and Gran Chaco ecoregions. Most experimental and modeling studies have focused on the resulting perturbations within Amazonia. Using the Regional Climate Model PRECIS, driven by ERA-40 reanalysis and ECHAM4 Baseline model for the period 1961-2000 (40-year runs), potential effects of deforestation/land-use changes in these and other neighboring ecoregions are evaluated. Current 2002 and estimated 2030 land-use scenarios are used to assess PRECIS's response during 1960-2000. ERA-40 and ECHAM4 Baseline driven runs yield similar results. Precipitation changes for 2002 and 2030 land-use scenarios, while significant within deforested areas, do not result in significant regional changes. For temperature significant changes are found within deforested areas and beyond, with major temperature enhancements during winter and spring. Given the current climate, primary effects of deforestation/land-use changes remain mostly confined to the tropical latitudes of Gran Chaco, and Amazonia.