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2011 1
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Page 1
Serum FGF19 predicts outcomes of Kasai portoenterostomy in biliary atresia.
Nyholm I, Hukkinen M, Pihlajoki M, Davidson JR, Tyraskis A, Lohi J, Heikkilä P, Hänninen S, Andersson N, Eloranta K, Carpén O, Heikinheimo M, Davenport M, Pakarinen MP. Nyholm I, et al. Hepatology. 2023 Apr 1;77(4):1263-1273. doi: 10.1097/HEP.0000000000000048. Epub 2023 Jan 3. Hepatology. 2023. PMID: 36692476 Free PMC article.
Patients with unsuccessful KPE (419 vs. 145 pg/mL, p =0.047), and those subsequently underwent liver transplantation (410 vs. 99 pg/mL, p =0.007) had significantly increased serum, but not liver, FGF19, which localized mainly in hepatocytes. In Cox hazard modeling s …
Patients with unsuccessful KPE (419 vs. 145 pg/mL, p =0.047), and those subsequently underwent liver transplantation (410 vs. 99 pg/m …
Deep learning quantification reveals a fundamental prognostic role for ductular reaction in biliary atresia.
Nyholm I, Sjöblom N, Pihlajoki M, Hukkinen M, Lohi J, Heikkilä P, Mutka A, Jahnukainen T, Davenport M, Heikinheimo M, Arola J, Pakarinen MP. Nyholm I, et al. Hepatol Commun. 2023 Dec 1;7(12):e0333. doi: 10.1097/HC9.0000000000000333. eCollection 2023 Dec 1. Hepatol Commun. 2023. PMID: 38051554 Free PMC article.
After KPE, patients with subsequent liver transplantation or death showed an increase in DR% (7.9%-9.9%, p = 0.04) and PIH% (1.6%-2.4%, p = 0.009), whereas patients with native liver survival (NLS) showed decreasing BE% (5.5%-3.0%, p = 0.03) and persistently …
After KPE, patients with subsequent liver transplantation or death showed an increase in DR% (7.9%-9.9%, p = 0.04) and PIH% (1.6%-2.4 …
Testicular steroidogenic cells to the rescue.
Heikinheimo M, Pihlajoki M, Schrade A, Kyrönlahti A, Wilson DB. Heikinheimo M, et al. Endocrinology. 2015 May;156(5):1616-9. doi: 10.1210/en.2015-1222. Endocrinology. 2015. PMID: 25886071 No abstract available.
Liver secretin receptor predicts portoenterostomy outcomes and liver injury in biliary atresia.
Godbole N, Nyholm I, Hukkinen M, Davidson JR, Tyraskis A, Lohi J, Heikkilä P, Eloranta K, Pihlajoki M, Davenport M, Heikinheimo M, Kyrönlahti A, Pakarinen MP. Godbole N, et al. Sci Rep. 2022 May 4;12(1):7233. doi: 10.1038/s41598-022-11140-9. Sci Rep. 2022. PMID: 35508528 Free PMC article.
Patients in the highest SCTR expression tertile showed 34-55% lower NLS than other groups at 1-5 years after PE (P = 0.006-0.04 for each year). SCTR expression was also significantly lower [42 (24-63) vs 75 (39-107) fold, P = 0.015] among those who normalized their …
Patients in the highest SCTR expression tertile showed 34-55% lower NLS than other groups at 1-5 years after PE (P = 0.006-0.04 for e …
GATA6 modulates the ductular reaction to bile duct ligation.
Pihlajoki M, Soini T, Cochran RB, Liljeström E, Huang J, Rudnick DA, Dietzen DJ, Kyrönlahti A, Pakarinen MP, Heikinheimo M, Wilson DB. Pihlajoki M, et al. Hepatol Int. 2021 Feb;15(1):166-178. doi: 10.1007/s12072-020-10119-w. Epub 2021 Jan 24. Hepatol Int. 2021. PMID: 33486744

Foci of fibrosis/necrosis, presumed to reflect patchy defects in bile duct formation, were observed in the livers of 37% of adult Alb-cre;Gata6(flox/flox) mice and 0% of controls (p < 0.05). Most notably, Alb-cre;Gata6(flox/flox) mice had an altered response to BDL mani

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Foci of fibrosis/necrosis, presumed to reflect patchy defects in bile duct formation, were observed in the livers of 37% of adult Alb-cre;Ga …
Compromised duodenal mucosal integrity in children with short bowel syndrome after adaptation to enteral autonomy.
Sanaksenaho G, Mutanen A, Godbole N, Hukkinen M, Merras-Salmio L, Kivisaari R, Kyrönlahti A, Pihlajoki M, Lohi J, Heikinheimo M, Pakarinen MP. Sanaksenaho G, et al. J Pediatr Surg. 2021 May;56(5):966-974. doi: 10.1016/j.jpedsurg.2020.09.065. Epub 2020 Oct 8. J Pediatr Surg. 2021. PMID: 33131778
RESULTS: Duodenal mucosa of SBS children showed increased histologic inflammation of lamina propria (p = 0.033) and mucosal mRNA expression of tumor necrosis factor (p = 0.027), transforming growth factor (TGF)-beta2 (p = 0.006) and caveolin-1 (CAV1; p …
RESULTS: Duodenal mucosa of SBS children showed increased histologic inflammation of lamina propria (p = 0.033) and mucosal mRNA expr …
The origin of plasma neutrophil gelatinase-associated lipocalin in cardiac surgery.
Passov A, Petäjä L, Pihlajoki M, Salminen US, Suojaranta R, Vento A, Andersson S, Pettilä V, Schramko A, Pesonen E. Passov A, et al. BMC Nephrol. 2019 May 22;20(1):182. doi: 10.1186/s12882-019-1380-4. BMC Nephrol. 2019. PMID: 31113394 Free PMC article. Clinical Trial.

In the "FINNAKI cohort", NGAL and lactoferrin concentrations correlated preoperatively (R = 0.59, p < 0.001) and at admission to the intensive care unit (R = 0.69, p < 0.001). At admission to intensive care unit, concentrations of NGAL and lactoferrin were hig

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In the "FINNAKI cohort", NGAL and lactoferrin concentrations correlated preoperatively (R = 0.59, p < 0.001) and at admission to t

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Analysis of Non-Relapsed and Relapsed Adult Type Granulosa Cell Tumors Suggests Stable Transcriptomes during Tumor Progression.
Andersson N, Haltia UM, Färkkilä A, Wong SC, Eloranta K, Wilson DB, Unkila-Kallio L, Pihlajoki M, Kyrönlahti A, Heikinheimo M. Andersson N, et al. Curr Issues Mol Biol. 2022 Jan 28;44(2):686-698. doi: 10.3390/cimb44020048. Curr Issues Mol Biol. 2022. PMID: 35723333 Free PMC article.
In relapsed tumors three genes were differentially expressed: plasmalemma vesicle associated protein (PLVAP) was upregulated (p = 0.01), whereas argininosuccinate synthase 1 (ASS1) (p = 0.01) and perilipin 4 (PLIN4) (p = 0.02) were downregulated. ...
In relapsed tumors three genes were differentially expressed: plasmalemma vesicle associated protein (PLVAP) was upregulated (p = 0.0 …
Neutrophil gelatinase-associated lipocalin does not originate from the kidney during reperfusion in clinical renal transplantation.
Passov A, Ilmakunnas M, Pihlajoki M, Hermunen K, Lempinen M, Helanterä I, Kailari V, Heikinheimo M, Andersson S, Pesonen E. Passov A, et al. Intensive Care Med Exp. 2021 Nov 22;9(1):56. doi: 10.1186/s40635-021-00422-7. Intensive Care Med Exp. 2021. PMID: 34807337 Free PMC article.
RESULTS: Significant renal release of LFABP [trans-renal gradient 8.4 (1.7-30.0) ng/ml, p = 0.005] and HFABP [trans-renal gradient 3.7 (1.1-5.0) ng/ml, p = 0.003] at 2 minutes after renal graft reperfusion indicated proximal and distal tubular damage. ...
RESULTS: Significant renal release of LFABP [trans-renal gradient 8.4 (1.7-30.0) ng/ml, p = 0.005] and HFABP [trans-renal gradient 3. …
15 results