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Nickel-Catalyzed Cross-Coupling of Aryl Chlorides with Aryl Grignard Reagents N-Heterocyclic Carbenes, Part 27. This work was supported by Aventis R&T, the Deutsche Forschungsgemeinschaft (DFG), the Bayerischer Forschungsverbund Katalyse (FORKAT), Degussa-Huls AG, and the Fonds der Chemischen Industrie (studentships for V.P.W.B. and T.W.). We thank C. Brossmer, K. Denk, R. W. Eckl, M. G. Gardiner, J. Schwarz, and C.-P. Reisinger for preparation of commercially unavailable ligands used in the screening assay and T. Boussie from Symyx Technologies for helpful discussions. Part 26: V. P. W. Bohm, C. W. K. Gstottmayr, T. Weskamp, W. A. Herrmann, J. Organomet. Chem. 2000, 595, 186-190.
Böhm VP, Weskamp T, Gstöttmayr CW, Herrmann WA. Böhm VP, et al. Angew Chem Int Ed Engl. 2000 May;39(9):1602-1604. doi: 10.1002/(sici)1521-3773(20000502)39:9<1602::aid-anie1602>3.0.co;2-n. Angew Chem Int Ed Engl. 2000. PMID: 10820447 No abstract available.
Dupilumab increases aspirin tolerance in NSAID-exacerbated respiratory disease.
Schneider S, Poglitsch K, Morgenstern C, Quint T, Gangl K, Sinz C, Bartosik T, Campion NJ, Liu DT, Landegger LD, Tu A, Stanek V, Rocha-Hasler M, Bangert C, Eckl-Dorna J. Schneider S, et al. Eur Respir J. 2023 Mar 16;61(3):2201335. doi: 10.1183/13993003.01335-2022. Print 2023 Mar. Eur Respir J. 2023. PMID: 36549708 Free PMC article.
Polyp burden was significantly reduced (total polyp score: -2.681.84, p<0.001), while pulmonary symptoms (asthma control test: +2.343.67, p<0.001) and olfactory performance improved (University of Pennsylvania Smell Identification Test: +11.169.54, p&lt …
Polyp burden was significantly reduced (total polyp score: -2.681.84, p<0.001), while pulmonary symptoms (asthma control test: +2. …
In Vitro Potential of the Acetone Leaf Extract and Fractions of Psychotria capensis (Eckl.) Vatke (Rubiaceae) to Combat Co-Infection of Tuberculosis and Helminthiasis.
Aro AO, Famuyide IM, Oyagbemi AA, Kabongo-Kayoka PN, McGaw LJ. Aro AO, et al. Front Pharmacol. 2022 Jan 11;12:744137. doi: 10.3389/fphar.2021.744137. eCollection 2021. Front Pharmacol. 2022. PMID: 35087402 Free PMC article.
Approximately a quarter of the world's population is currently infected with M. tuberculosis, and about 10% of those infected will develop into active disease, particularly immune compromised individuals. ...In addition, the anti-inflammatory and immunomodulatory effect of …
Approximately a quarter of the world's population is currently infected with M. tuberculosis, and about 10% of those infected will de …
Dual HER2 blockade with pertuzumab (P) and trastuzumab (T) in patients with HER2-positive metastatic breast cancer (mBC) relapsing after adjuvant treatment with T: results from a German non-interventional study (NIS) HELENA (NCT01777958).
Thill M, Wimberger P, Grafe A, Klare P, Luedtke-Heckenkamp K, Reichert D, Zaiss M, Ziegler-Löhr K, Eckl T, Schneeweiss A. Thill M, et al. Breast Cancer Res Treat. 2022 Nov;196(2):311-321. doi: 10.1007/s10549-022-06710-4. Epub 2022 Sep 12. Breast Cancer Res Treat. 2022. PMID: 36094611 Free PMC article.
METHODS: Between 06/2013 through 07/2016, 126 patients (in-label use of P at study start = full analysis set, FAS) in 81 German study sites were included. ...Safety (SAF): 93.9% of patients had an adverse event (AE), 32.6% a serious AE (SAE). AEs related to P occurr …
METHODS: Between 06/2013 through 07/2016, 126 patients (in-label use of P at study start = full analysis set, FAS) in 81 German study …
Plasma fatty acids and kidney function decline in post-myocardial infarction patients of the Alpha Omega Cohort.
van Westing AC, Eckl MR, Küpers LK, Pertiwi K, Hoogeveen EK, Geleijnse JM. van Westing AC, et al. Nutr Metab Cardiovasc Dis. 2021 May 6;31(5):1467-1476. doi: 10.1016/j.numecd.2021.01.012. Epub 2021 Jan 29. Nutr Metab Cardiovasc Dis. 2021. PMID: 33744039 Free article.
Plasma FAs (% total FAs) in cholesteryl esters were assessed at baseline (2002-2006), and 40 months change in creatinine-cystatin C based glomerular filtration rate was estimated (eGFR, in ml/min per 1.73 m(2)). Beta coefficients for annual eGFR change in relation to plasm …
Plasma FAs (% total FAs) in cholesteryl esters were assessed at baseline (2002-2006), and 40 months change in creatinine-cystatin C based gl …
Quantification of gait changes in subjects with visual height intolerance when exposed to heights.
Schniepp R, Kugler G, Wuehr M, Eckl M, Huppert D, Huth S, Pradhan C, Jahn K, Brandt T. Schniepp R, et al. Front Hum Neurosci. 2014 Dec 4;8:963. doi: 10.3389/fnhum.2014.00963. eCollection 2014. Front Hum Neurosci. 2014. PMID: 25538595 Free PMC article.
MATERIALS AND METHODS: Sixteen subjects with vHI walked over a gait mat (GAITRite) on a 15-m-high balcony and at ground-level. Subjects walked at different speeds (slow, preferred, fast), during changes of the visual input (gaze straight/up/down; eyes open/closed), and whi …
MATERIALS AND METHODS: Sixteen subjects with vHI walked over a gait mat (GAITRite) on a 15-m-high balcony and at ground-level. Subjec …
Induction of sister chromatid exchanges in cultured adult rat hepatocytes by directly and indirectly acting mutagens/carcinogens.
Eckl PM, Strom SC, Michalopoulos G, Jirtle RL. Eckl PM, et al. Carcinogenesis. 1987 Aug;8(8):1077-83. doi: 10.1093/carcin/8.8.1077. Carcinogenesis. 1987. PMID: 3111742
The approximate drug concentrations leading to a doubling of control SCE levels were 2.5 X 10(-4) M for cyclophosphamide, 4.5 X 10(-5) M for dimethylnitrosamine, 2.5 X 10(-6) M for N-methyl-N-nitro-N-nitrosoguanidine, 2 X 10(-10) M for aflatoxin B1 (AF …
The approximate drug concentrations leading to a doubling of control SCE levels were 2.5 X 10(-4) M for cyclophosphamide, 4.5 X 10(-5 …