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Influence of Roll Speed during Roll Compaction and Its Effect on the Prediction of Ribbon Solid Fraction.
Lück M, De Saeger M, Kleinebudde P. Lück M, et al. Pharmaceutics. 2022 Nov 7;14(11):2399. doi: 10.3390/pharmaceutics14112399. Pharmaceutics. 2022. PMID: 36365219 Free PMC article.
Microcrystalline cellulose (MCC) and lactose were compressed at several maximum roll pressures (P(max)) and RS combinations using a gap-controlled roll compactor. ...However, this effect can be overcome or reduced by adjusting P(max) above the yield pre …
Microcrystalline cellulose (MCC) and lactose were compressed at several maximum roll pressures (P(max)) and RS combinations using a g …
Applications of terahertz pulsed imaging to sustained-release tablet film coating quality assessment and dissolution performance.
Ho L, Müller R, Gordon KC, Kleinebudde P, Pepper M, Rades T, Shen Y, Taday PF, Zeitler JA. Ho L, et al. J Control Release. 2008 Apr 7;127(1):79-87. doi: 10.1016/j.jconrel.2008.01.002. Epub 2008 Jan 12. J Control Release. 2008. PMID: 18291547
The results from the dissolution tests revealed significant differences in the product performance between the lab and pilot scales (Student t-test, P<0.05). The model-independent dissolution parameters in the pilot scale showed a prolonged mean dissolution time. ...
The results from the dissolution tests revealed significant differences in the product performance between the lab and pilot scales (Student …
Roll compaction/dry granulation: comparison between roll mill and oscillating granulator in dry granulation.
Sakwanichol J, Puttipipatkhachorn S, Ingenerf G, Kleinebudde P. Sakwanichol J, et al. Pharm Dev Technol. 2012 Jan-Feb;17(1):30-9. doi: 10.3109/10837450.2010.508078. Epub 2010 Aug 23. Pharm Dev Technol. 2012. PMID: 20731538

All milling parameters in both milling types affected significantly the median particle size, size distribution and amount of fine particles (P < 0.05), except the rotor types of oscillating granulator on fines. Only three milling parameters influenced significantly the

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All milling parameters in both milling types affected significantly the median particle size, size distribution and amount of fine particles …