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Tablet formulation of Famotidine-loaded P-gp inhibiting nanoparticles using PLA-g-PEG grafted polymer.
Mokhtar M, Gosselin PM, François-Xavier L, Hildgen P. Mokhtar M, et al. Pharm Dev Technol. 2019 Feb;24(2):211-221. doi: 10.1080/10837450.2018.1455695. Epub 2018 Apr 4. Pharm Dev Technol. 2019. PMID: 29564944
Our work aimed at evaluating the use of permeability glycoprotein (P-gp) inhibiting nanoparticles (NPs) as a part of a suitable oral solid dosage to improve bioavailability. ...This could therefore represent an attractive formulation alternative to enhance oral permeabilit …
Our work aimed at evaluating the use of permeability glycoprotein (P-gp) inhibiting nanoparticles (NPs) as a part of a suitable oral …
Design of PEG-grafted-PLA nanoparticles as oral permeability enhancer for P-gp substrate drug model Famotidine.
Mokhtar M, Gosselin P, Lacasse F, Hildgen P. Mokhtar M, et al. J Microencapsul. 2017 Feb;34(1):91-103. doi: 10.1080/02652048.2017.1290155. J Microencapsul. 2017. PMID: 28151040
Bioavailability of oral drugs can be limited by an intestinal excretion process mediated by P-glycoprotein (P-gp). Polyethylene glycol (PEG) is a known P-gp inhibitor. ...NPs prepared from PLA-g-PEG5% are promising to improve oral bioavailability of P- …
Bioavailability of oral drugs can be limited by an intestinal excretion process mediated by P-glycoprotein (P-gp). Polyethylen …
Artificial neural network modeling for drug dialyzability prediction.
Daheb K, Lipman ML, Hildgen P, Roy JJ. Daheb K, et al. J Pharm Pharm Sci. 2013;16(5):665-75. doi: 10.18433/j35c8b. J Pharm Pharm Sci. 2013. PMID: 24393550 Free article.
The addition of BSA in the physiologic buffer statistically significantly decreased CLD for carvedilol (p= 0.002) and labetalol (p<0.001), but made no significant difference for atenolol (p= 0.100). In contrast, varying UFR does not significantly affect CL …
The addition of BSA in the physiologic buffer statistically significantly decreased CLD for carvedilol (p= 0.002) and labetalol (p
Tailored Nanocarriers for the Pulmonary Delivery of Levofloxacin against Pseudomonas aeruginosa: A Comparative Study.
Derbali RM, Aoun V, Moussa G, Frei G, Tehrani SF, Del'Orto JC, Hildgen P, Roullin VG, Chain JL. Derbali RM, et al. Mol Pharm. 2019 May 6;16(5):1906-1916. doi: 10.1021/acs.molpharmaceut.8b01256. Epub 2019 Apr 4. Mol Pharm. 2019. PMID: 30900903
Despite their negative surface charge, liposomes still interacted with the P. aeruginosa membrane in a dose-response manner, as demonstrated by flow cytometry. ...Finally, nebulization of anionic liposomes containing levofloxacin did not impact their colloidal stability, a …
Despite their negative surface charge, liposomes still interacted with the P. aeruginosa membrane in a dose-response manner, as demon …
27 results