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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1963 1
1964 1
1965 1
1966 1
1968 1
1971 2
1972 1
1973 1
1974 3
1975 49
1976 63
1977 49
1978 64
1979 74
1980 64
1981 78
1982 83
1983 97
1984 106
1985 103
1986 94
1987 117
1988 120
1989 160
1990 196
1991 196
1992 248
1993 253
1994 342
1995 347
1996 375
1997 492
1998 570
1999 622
2000 675
2001 734
2002 842
2003 874
2004 978
2005 1134
2006 1087
2007 1122
2008 1328
2009 1472
2010 1565
2011 1739
2012 2041
2013 2341
2014 2777
2015 3046
2016 3162
2017 3331
2018 3558
2019 3603
2020 4270
2021 5004
2022 5419
2023 5120
2024 2304

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58,516 results

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Page 1
Exosomal transfer of p-STAT3 promotes acquired 5-FU resistance in colorectal cancer cells.
Zhang Q, Liu RX, Chan KW, Hu J, Zhang J, Wei L, Tan H, Yang X, Liu H. Zhang Q, et al. J Exp Clin Cancer Res. 2019 Jul 19;38(1):320. doi: 10.1186/s13046-019-1314-9. J Exp Clin Cancer Res. 2019. PMID: 31324203 Free PMC article.
METHODS: Exosomes from a 5-FU-resistant cell line (RKO/R) and its parental cell line RKO/P were isolated and co-cultured with 5-FU-sensitive cells. ...Proteomics and WB analysis results indicated that GSTP1 and p-STAT3 (Tyr705) were enriched in exosome …
METHODS: Exosomes from a 5-FU-resistant cell line (RKO/R) and its parental cell line RKO/P were isolated and co-cultured with …
Curcumin Reverses 5-Fluorouracil Resistance by Promoting Human Colon Cancer HCT-8/5-FU Cell Apoptosis and Down-regulating Heat Shock Protein 27 and P-Glycoprotein.
He WT, Zhu YH, Zhang T, Abulimiti P, Zeng FY, Zhang LP, Luo LJ, Xie XM, Zhang HL. He WT, et al. Chin J Integr Med. 2019 Jun;25(6):416-424. doi: 10.1007/s11655-018-2997-z. Epub 2018 Nov 27. Chin J Integr Med. 2019. PMID: 30484020
The mRNA levels of P-gp (0.280.02) and HSP-27 (0.280.09) in HCT-8/5-FU cells treated with combination drugs were lower than cells treated with 5-FU alone (P-gp, 0.480.07, P=0.009; HSP-27, 0.570.10, P=0.007). The protein levels of P …
The mRNA levels of P-gp (0.280.02) and HSP-27 (0.280.09) in HCT-8/5-FU cells treated with combination drugs were lower than ce …
LY294002 may overcome 5-FU resistance via down-regulation of activated p-AKT in Epstein-Barr virus-positive gastric cancer cells.
Shin JY, Kim JO, Lee SK, Chae HS, Kang JH. Shin JY, et al. BMC Cancer. 2010 Aug 13;10:425. doi: 10.1186/1471-2407-10-425. BMC Cancer. 2010. PMID: 20704765 Free PMC article.
The expression of p-AKT and p-NF kappaB was upregulated by 5-FU alone but sequential treatment of 5-FU and LY decreased the expression of both p-AKT and p-NF kappaB. ...In sequential combination of 5-FU and LY, the expression of …
The expression of p-AKT and p-NF kappaB was upregulated by 5-FU alone but sequential treatment of 5-FU and LY de …
Selective delivery of 5-fluorouracil (5-FU) to i.p. tissues using 5-FU microspheres in rats.
Hagiwara A, Sakakura C, Tsujimoto H, Imanishi T, Ohgaki M, Yamasaki J, Sawai K, Takahashi T, Fujita T, Yamamoto A, Muranishi S, Ikada Y. Hagiwara A, et al. Anticancer Drugs. 1997 Feb;8(2):182-8. doi: 10.1097/00001813-199702000-00009. Anticancer Drugs. 1997. PMID: 9073314
The incorporated 5-FU is released slowly over a 3 week period. We investigated the drug distribution and pharmacokinetics of 5-FU in rats receiving an i.p. injection of 5-FU-MS or aqueous 5-FU solution. The concentration of 5-FU was highe …
The incorporated 5-FU is released slowly over a 3 week period. We investigated the drug distribution and pharmacokinetics of 5-FU …
5-FU and the dietary flavonoid carvacrol: a synergistic combination that induces apoptosis in MCF-7 breast cancer cells.
Azimi S, Esmaeil Lashgarian H, Ghorbanzadeh V, Moradipour A, Pirzeh L, Dariushnejad H. Azimi S, et al. Med Oncol. 2022 Oct 12;39(12):253. doi: 10.1007/s12032-022-01863-0. Med Oncol. 2022. PMID: 36224408
Incubation of the cells with carvacrol neutralized P-glycoprotein overexpression in qPCR assay (P 0.05). Compared with adding verapamil (a P-glycoprotein inhibitor) to 5-FU, the combination of carvacrol and 5-FU caused a further increase in the …
Incubation of the cells with carvacrol neutralized P-glycoprotein overexpression in qPCR assay (P 0.05). Compared with adding …
Kung-fu versus swimming training and the effects on balance abilities in young adolescents.
Baccouch R, Rebai H, Sahli S. Baccouch R, et al. Phys Ther Sport. 2015 Nov;16(4):349-54. doi: 10.1016/j.ptsp.2015.01.004. Epub 2015 Feb 7. Phys Ther Sport. 2015. PMID: 26095581
RESULTS: Kung-fu practitioners control their balance (P < .05) better than controls and swimmers in the unipedal posture when visual inputs are available. Kung-fu training improved (P < .05) the bipedal balance control in the EO condition. ...

RESULTS: Kung-fu practitioners control their balance (P < .05) better than controls and swimmers in the unipedal posture wh

…
NDRG4 sensitizes CRC cells to 5-FU by upregulating DDIT3 expression.
Li R, He C, Shen L, Wang S, Shen Y, Feng F, Zhang J, Zheng J. Li R, et al. Oncol Lett. 2021 Nov;22(5):782. doi: 10.3892/ol.2021.13043. Epub 2021 Sep 13. Oncol Lett. 2021. PMID: 34594423 Free PMC article.
The incidence of colorectal cancer (CRC) has remained high in recent years, and 5-fluorouracil (5-FU) is a vital chemotherapeutic agent for its treatment. Our previous study reported that N-myc downstream-regulated gene 4 (NDRG4) plays a tumor-suppressive role in CRC, but …
The incidence of colorectal cancer (CRC) has remained high in recent years, and 5-fluorouracil (5-FU) is a vital chemotherapeutic age …
Mesenchymal stem cell-derived exosomes loaded with 5-Fu against cholangiocarcinoma in vitro.
Chen M, Li Y, Ma N, Zang J. Chen M, et al. Mol Med Rep. 2022 Jun;25(6):213. doi: 10.3892/mmr.2022.12729. Epub 2022 May 11. Mol Med Rep. 2022. PMID: 35543159 Free PMC article.
Both the incubation and sonication methods successfully loaded 5-Fu into the exosomes (5-Fu-Exos), with the sonication method having a higher loading efficiency than the incubation method. When compared to the free 5-Fu group, the 5-Fu-Exos group signi …
Both the incubation and sonication methods successfully loaded 5-Fu into the exosomes (5-Fu-Exos), with the sonication method …
Regional and systemic therapies for advanced colorectal carcinoma: randomized clinical trial results.
Benson AB 3rd. Benson AB 3rd. Oncology (Williston Park). 1998 Oct;12(10 Suppl 7):28-34. Oncology (Williston Park). 1998. PMID: 9830622 Free article. Review.
There was a significant difference in survival for patients with nonmeasurable disease (16.9 months) compared to those with measurable disease (12.6 months, P = .001). The Advanced Colorectal Cancer Meta-analysis Project demonstrated a response advantage for patients recei …
There was a significant difference in survival for patients with nonmeasurable disease (16.9 months) compared to those with measurable disea …
Insulin reverses choriocarcinoma 5- fluorouracil resistance.
Shan Y, Li Y, Han H, Jiang C, Zhang H, Hu J, Sun H, Zhu J. Shan Y, et al. Bioengineered. 2021 Dec;12(1):2087-2094. doi: 10.1080/21655979.2021.1931643. Bioengineered. 2021. PMID: 34034636 Free PMC article.
Results showed that insulin combined with 5-FU suppressed cell viability by 30% in JEG-3 and 43% in JAR compared with 5-FU alone in 72 h. What's more, insulin combined with 5-FU promoted cell apoptosis, inhibited cell proliferation, migration, and phosphoryla …
Results showed that insulin combined with 5-FU suppressed cell viability by 30% in JEG-3 and 43% in JAR compared with 5-FU alo …
58,516 results
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