AB569, a nontoxic chemical tandem that kills major human pathogenic bacteria.
McDaniel CT, Panmanee W, Winsor GL, Gill E, Bertelli C, Schurr MJ, Dongare P, Paul AT, Ko SB, Lau GW, Dasgupta N, Bogue AL, Miller WE, Mortensen JE, Haslam DB, Dexheimer P, Muruve DA, Aronow BJ, Forbes MDE, Danilczuk M, Brinkman FSL, Hancock REW, Meyer TJ, Hassett DJ.
McDaniel CT, et al.
Proc Natl Acad Sci U S A. 2020 Mar 3;117(9):4921-4930. doi: 10.1073/pnas.1911927117. Epub 2020 Feb 18.
Proc Natl Acad Sci U S A. 2020.
PMID: 32071223
Free PMC article.
AB569 was not toxic to human cell lines at bactericidal concentrations using a basic viability assay. RNA-Seq analyses upon treatment of P. aeruginosa with AB569 revealed a catastrophic loss of the ability to support core pathways encompassing DNA, RNA, protein, ATP biosyn …
AB569 was not toxic to human cell lines at bactericidal concentrations using a basic viability assay. RNA-Seq analyses upon treatment of …