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2008 1
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Intensity-modulated radiotherapy versus stereotactic body radiotherapy for prostate cancer (PACE-B): 2-year toxicity results from an open-label, randomised, phase 3, non-inferiority trial.
Tree AC, Ostler P, van der Voet H, Chu W, Loblaw A, Ford D, Tolan S, Jain S, Martin A, Staffurth J, Armstrong J, Camilleri P, Kancherla K, Frew J, Chan A, Dayes IS, Duffton A, Brand DH, Henderson D, Morrison K, Brown S, Pugh J, Burnett S, Mahmud M, Hinder V, Naismith O, Hall E, van As N; PACE Trial Investigators. Tree AC, et al. Lancet Oncol. 2022 Oct;23(10):1308-1320. doi: 10.1016/S1470-2045(22)00517-4. Epub 2022 Sep 13. Lancet Oncol. 2022. PMID: 36113498 Free article. Clinical Trial.
At 24 months, RTOG grade 2 or worse genitourinary toxicity was seen in eight (2%) of 381 participants assigned to CRT and 13 (3%) of 384 participants assigned to SBRT (absolute difference 1.3% [95% CI -1.3 to 4.0]; p=0.39); RTOG grade 2 or worse gastrointestinal toxicity w …
At 24 months, RTOG grade 2 or worse genitourinary toxicity was seen in eight (2%) of 381 participants assigned to CRT and 13 (3%) of 384 par …
Intensity-modulated fractionated radiotherapy versus stereotactic body radiotherapy for prostate cancer (PACE-B): acute toxicity findings from an international, randomised, open-label, phase 3, non-inferiority trial.
Brand DH, Tree AC, Ostler P, van der Voet H, Loblaw A, Chu W, Ford D, Tolan S, Jain S, Martin A, Staffurth J, Camilleri P, Kancherla K, Frew J, Chan A, Dayes IS, Henderson D, Brown S, Cruickshank C, Burnett S, Duffton A, Griffin C, Hinder V, Morrison K, Naismith O, Hall E, van As N; PACE Trial Investigators. Brand DH, et al. Lancet Oncol. 2019 Nov;20(11):1531-1543. doi: 10.1016/S1470-2045(19)30569-8. Epub 2019 Sep 17. Lancet Oncol. 2019. PMID: 31540791 Free PMC article. Clinical Trial.
Worst acute RTOG gastrointestinal toxic effect proportions were as follows: grade 2 or more severe toxic events in 53 (12%) of 432 patients in the conventionally fractionated or moderately hypofractionated radiotherapy group versus 43 (10%) of 415 patients in the stereotactic bod …
Worst acute RTOG gastrointestinal toxic effect proportions were as follows: grade 2 or more severe toxic events in 53 (12%) of 432 patients …
Androgen deprivation therapy and radiotherapy in intermediate-risk prostate cancer: A randomised phase III trial.
Nabid A, Carrier N, Vigneault E, Van Nguyen T, Vavassis P, Brassard MA, Bahoric B, Archambault R, Vincent F, Bettahar R, Wilke D, Souhami L. Nabid A, et al. Eur J Cancer. 2021 Jan;143:64-74. doi: 10.1016/j.ejca.2020.10.023. Epub 2020 Dec 3. Eur J Cancer. 2021. PMID: 33279855 Clinical Trial.

FINDINGS: With a median follow-up of 11.3 years (interquartile range: 10.9-11.7), patients receiving DERT76 alone, compared with patients receiving ADT + RT70 and ADT + DERT76, had higher rates of BF (32%, 18% and 14%, respectively, p < 0.001), higher rates of prostate

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FINDINGS: With a median follow-up of 11.3 years (interquartile range: 10.9-11.7), patients receiving DERT76 alone, compared with patients re …
Optimizing Treatment in Intermediate-Risk Prostate Cancer: Secondary Analysis of a Randomized Phase 3 Trial.
Nabid A, Carrier N, Vigneault E, Van Nguyen T, Vavassis P, Brassard MA, Bahoric B, Archambault R, Vincent F, Bettahar R, Wilke D, Souhami L. Nabid A, et al. Int J Radiat Oncol Biol Phys. 2021 Nov 1;111(3):732-740. doi: 10.1016/j.ijrobp.2021.04.013. Epub 2021 Apr 24. Int J Radiat Oncol Biol Phys. 2021. PMID: 33901566 Clinical Trial.
UIR patients had significantly worse DMFS (hazard ratio [95% confidence interval], 1.61 [1.20-2.15]; P = .026) and OS (1.51 [1.12-2.04]; P = .0495) and a nonsignificant higher cumulative incidence of BF rate (1.55 [0.98-2.47]; P = .08). ...
UIR patients had significantly worse DMFS (hazard ratio [95% confidence interval], 1.61 [1.20-2.15]; P = .026) and OS (1.51 [1.12-2.0 …
Testosterone recovery after androgen deprivation therapy in localised prostate cancer: Long-term data from two randomised trials.
Nabid A, Carrier N, Vigneault E, Martin AG, Bahary JP, Van Nguyen T, Vavassis P, Vass S, Brassard MA, Bahoric B, Archambault R, Vincent F, Bettahar R, Duclos M, Wilke D, Souhami L. Nabid A, et al. Radiother Oncol. 2024 Mar 27;195:110256. doi: 10.1016/j.radonc.2024.110256. Online ahead of print. Radiother Oncol. 2024. PMID: 38552845

RESULTS: Overall, 87.4 % (167/191), 75.9 % (293/386), 54.8 % (181/330) and 43.2 % (80/185) of pts, recovered normal T on the 0-, 6-, 18- or 36-month schedule, respectively (p < 0.001). In patients recovering normal T, the median time to T recovery increased with ADT dur

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RESULTS: Overall, 87.4 % (167/191), 75.9 % (293/386), 54.8 % (181/330) and 43.2 % (80/185) of pts, recovered normal T on the 0-, 6-, 18- or …
Respiratory Motion, Anterior Heart Displacement and Heart Dosimetry: Comparison Between Prone (Pr) and Supine (Su) Whole Breast Irradiation.
Lakosi F, Gulyban A, Janvary L, Simoni SB, Jansen N, Seidel L, Kovacs A, Vavassis P, Coucke P. Lakosi F, et al. Pathol Oncol Res. 2015 Sep;21(4):1051-8. doi: 10.1007/s12253-015-9932-9. Epub 2015 Apr 4. Pathol Oncol Res. 2015. PMID: 25840562 Free article.

Prone positioning significantly reduced both the mean 3D vectorial displacements (1.1 0.6 (Pr) vs. 2.0 0.9 mm (Su), p < 0.01) and their variability (0.3 0.2 vs. 0.5 0.3 mm, p = 0.01). Respiration-induced volumetric changes of CW were also significantly lower in P

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Prone positioning significantly reduced both the mean 3D vectorial displacements (1.1 0.6 (Pr) vs. 2.0 0.9 mm (Su), p < 0.01) and

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The Influence of Treatment Position (Prone vs. Supine) on Clip Displacement, Seroma, Tumor Bed and Partial Breast Target Volumes: Comparative Study.
Lakosi F, Gulyban A, Simoni SB, Nguyen PV, Cucchiaro S, Seidel L, Janvary L, Nicolas S, Vavassis P, Coucke P. Lakosi F, et al. Pathol Oncol Res. 2016 Jul;22(3):493-500. doi: 10.1007/s12253-015-0028-3. Epub 2015 Dec 16. Pathol Oncol Res. 2016. PMID: 26676979 Free article.
The IDR was significantly larger in Su than in Pr (7.6 vs. 4.1 p < 0.01). Clip displacements varied considerably with respect to their relative position to the CW. ...

The IDR was significantly larger in Su than in Pr (7.6 vs. 4.1 p < 0.01). Clip displacements varied considerably with respect to t

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Phase 2 study of silver leaf dressing for treatment of radiation-induced dermatitis in patients receiving radiotherapy to the head and neck.
Vavassis P, Gelinas M, Chabot Tr J, Nguyen-Tân PF. Vavassis P, et al. J Otolaryngol Head Neck Surg. 2008 Feb;37(1):124-9. J Otolaryngol Head Neck Surg. 2008. PMID: 18479639 Clinical Trial.
Sign test analysis indicated that the use of silver-leaf dressing gave significantly superior results when compared with silver sulfadiazine (p = .035). CONCLUSION: Silver leaf dressing does not appear to be superior to our standard treatment for radiation-induced dermatit …
Sign test analysis indicated that the use of silver-leaf dressing gave significantly superior results when compared with silver sulfadiazine …
External beam accelerated partial breast irradiation versus whole breast irradiation after breast conserving surgery in women with ductal carcinoma in situ and node-negative breast cancer (RAPID): a randomised controlled trial.
Whelan TJ, Julian JA, Berrang TS, Kim DH, Germain I, Nichol AM, Akra M, Lavertu S, Germain F, Fyles A, Trotter T, Perera FE, Balkwill S, Chafe S, McGowan T, Muanza T, Beckham WA, Chua BH, Gu CS, Levine MN, Olivotto IA; RAPID Trial Investigators. Whelan TJ, et al. Lancet. 2019 Dec 14;394(10215):2165-2172. doi: 10.1016/S0140-6736(19)32515-2. Epub 2019 Dec 5. Lancet. 2019. PMID: 31813635 Clinical Trial.
Acute radiation toxicity (grade 2, within 3 months of radiotherapy start) occurred less frequently in patients treated with APBI (300 [28%] of 1070 patients) than whole breast irradiation (484 [45%] of 1065 patients, p<0.0001). Late radiation toxicity (grade 2, later th …
Acute radiation toxicity (grade 2, within 3 months of radiotherapy start) occurred less frequently in patients treated with APBI (300 [28%] …