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Page 1
Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction.
McMurray JJV, Solomon SD, Inzucchi SE, Køber L, Kosiborod MN, Martinez FA, Ponikowski P, Sabatine MS, Anand IS, Bělohlávek J, Böhm M, Chiang CE, Chopra VK, de Boer RA, Desai AS, Diez M, Drozdz J, Dukát A, Ge J, Howlett JG, Katova T, Kitakaze M, Ljungman CEA, Merkely B, Nicolau JC, O'Meara E, Petrie MC, Vinh PN, Schou M, Tereshchenko S, Verma S, Held C, DeMets DL, Docherty KF, Jhund PS, Bengtsson O, Sjöstrand M, Langkilde AM; DAPA-HF Trial Committees and Investigators. McMurray JJV, et al. N Engl J Med. 2019 Nov 21;381(21):1995-2008. doi: 10.1056/NEJMoa1911303. Epub 2019 Sep 19. N Engl J Med. 2019. PMID: 31535829 Clinical Trial.
RESULTS: Over a median of 18.2 months, the primary outcome occurred in 386 of 2373 patients (16.3%) in the dapagliflozin group and in 502 of 2371 patients (21.2%) in the placebo group (hazard ratio, 0.74; 95% confidence interval [CI], 0.65 to 0.85; P<0.001). A first wor …
RESULTS: Over a median of 18.2 months, the primary outcome occurred in 386 of 2373 patients (16.3%) in the dapagliflozin group and in 502 of …
Dapagliflozin in Heart Failure with Mildly Reduced or Preserved Ejection Fraction.
Solomon SD, McMurray JJV, Claggett B, de Boer RA, DeMets D, Hernandez AF, Inzucchi SE, Kosiborod MN, Lam CSP, Martinez F, Shah SJ, Desai AS, Jhund PS, Belohlavek J, Chiang CE, Borleffs CJW, Comin-Colet J, Dobreanu D, Drozdz J, Fang JC, Alcocer-Gamba MA, Al Habeeb W, Han Y, Cabrera Honorio JW, Janssens SP, Katova T, Kitakaze M, Merkely B, O'Meara E, Saraiva JFK, Tereshchenko SN, Thierer J, Vaduganathan M, Vardeny O, Verma S, Pham VN, Wilderäng U, Zaozerska N, Bachus E, Lindholm D, Petersson M, Langkilde AM; DELIVER Trial Committees and Investigators. Solomon SD, et al. N Engl J Med. 2022 Sep 22;387(12):1089-1098. doi: 10.1056/NEJMoa2206286. Epub 2022 Aug 27. N Engl J Med. 2022. PMID: 36027570 Clinical Trial.
RESULTS: Over a median of 2.3 years, the primary outcome occurred in 512 of 3131 patients (16.4%) in the dapagliflozin group and in 610 of 3132 patients (19.5%) in the placebo group (hazard ratio, 0.82; 95% confidence interval [CI], 0.73 to 0.92; P<0.001). Worsening hea …
RESULTS: Over a median of 2.3 years, the primary outcome occurred in 512 of 3131 patients (16.4%) in the dapagliflozin group and in 610 of 3 …
Thermodynamic scaling of molecular dynamics in supercooled ibuprofen.
Adrjanowicz K, Wojnarowska Z, Paluch M, Pionteck J. Adrjanowicz K, et al. J Phys Chem B. 2011 Apr 28;115(16):4559-67. doi: 10.1021/jp109135w. Epub 2011 Apr 1. J Phys Chem B. 2011. PMID: 21456562
For such hydrogen-bonded liquids, superpositioning of dynamics under various temperature T, pressure P, and volume V conditions, when plotted versus the scaling function of T(-1)V(-gamma) (where gamma is a material constant), may not always be satisfying. ... …
For such hydrogen-bonded liquids, superpositioning of dynamics under various temperature T, pressure P, and volume V condition …
Use of alfentanil and propofol for outpatient monitored anesthesia care: determining the optimal dosing regimen.
Avramov MN, White PF. Avramov MN, et al. Anesth Analg. 1997 Sep;85(3):566-72. doi: 10.1097/00000539-199709000-00015. Anesth Analg. 1997. PMID: 9296410 Clinical Trial.
Two minutes before the infiltration of the local anesthetic solution, a bolus of alfentanil, 2.5 microg/kg I.V., was administered, followed by a maintenance infusion of 0.5 microg x kg(-1) x min(-1). ...Propofol produced dose-dependent increases in the level of sedation (w …
Two minutes before the infiltration of the local anesthetic solution, a bolus of alfentanil, 2.5 microg/kg I.V., was administered, fo …
Segregated parallel inputs to the brachial spinal cord from the cingulate motor cortex in the monkey.
Morecraft RJ, Louie JL, Schroeder CM, Avramov K. Morecraft RJ, et al. Neuroreport. 1997 Dec 22;8(18):3933-8. Neuroreport. 1997. PMID: 9462469
In M3 cases, contralateral terminal label occurred in the lateral part of laminae V and VI of the intermediate zone including the reticulated marginal border. ...In marked contrast, M4 cases demonstrated contralateral terminal labeling in the medial part of the dorsal and …
In M3 cases, contralateral terminal label occurred in the lateral part of laminae V and VI of the intermediate zone including the ret …
[Role of histidine in ligand binding ability of hemoglobin gene].
Romanova TA, Krasnov PO, Kuzubov AA, Avramov PV. Romanova TA, et al. Bioorg Khim. 2004 Mar-Apr;30(2):141-5. doi: 10.1023/b:rubi.0000023096.21469.8e. Bioorg Khim. 2004. PMID: 15143668 Russian.
The Mulliken population analysis showed that the electronic density of ligand (oxygen or nitrogen oxide) p-orbitals is transferred to the d-orbitals of the Fe atom, whose charge, calculated according to the Mulliken analysis, formally becomes negative. ...
The Mulliken population analysis showed that the electronic density of ligand (oxygen or nitrogen oxide) p-orbitals is transferred to …