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Did you mean P. udhayakumar (199 results)?
Comprehensive in silico screening and molecular dynamics studies of missense mutations in Sjogren-Larsson syndrome associated with the ALDH3A2 gene.
Udhaya Kumar S, Thirumal Kumar D, Mandal PD, Sankar S, Haldar R, Kamaraj B, Walter CEJ, Siva R, George Priya Doss C, Zayed H. Udhaya Kumar S, et al. Adv Protein Chem Struct Biol. 2020;120:349-377. doi: 10.1016/bs.apcsb.2019.11.004. Epub 2020 Feb 4. Adv Protein Chem Struct Biol. 2020. PMID: 32085885 Review.
These mutations were examined with various in silico stability tools, which predicted that the mutations p.S308N and p.R423H that are located at the protein-protein interaction domains are the most destabilizing. Furthermore, to determine the atomistic-level differe …
These mutations were examined with various in silico stability tools, which predicted that the mutations p.S308N and p.R423H t …
Mutations in ARSB in MPS VI patients in India.
Mathew J, Jagadeesh SM, Bhat M, Udhaya Kumar S, Thiyagarajan S, Srinivasan S. Mathew J, et al. Among authors: udhaya kumar s. Mol Genet Metab Rep. 2015 Jul 17;4:53-61. doi: 10.1016/j.ymgmr.2015.06.002. eCollection 2015 Sep. Mol Genet Metab Rep. 2015. PMID: 26937411 Free PMC article.
Both familial mutations were found in seven families, and only one mutation was found in one family. Seven mutations were found - four novel (p.G38_G40del3, p.C91R, p.L98R and p.R315P), two previously reported from India (p.D53N and p.W45 …
Both familial mutations were found in seven families, and only one mutation was found in one family. Seven mutations were found - four novel …
Analysis of signaling cascades from myeloma cells treated with pristimerin.
Almaghrbi H, Elkardawy R, Udhaya Kumar S, Kuttikrishnan S, Abunada T, Kashyap MK, Ahmad A, Uddin S, George Priya Doss C, Zayed H. Almaghrbi H, et al. Among authors: udhaya kumar s. Adv Protein Chem Struct Biol. 2023;134:147-174. doi: 10.1016/bs.apcsb.2022.10.006. Epub 2022 Nov 16. Adv Protein Chem Struct Biol. 2023. PMID: 36858733
We screened the most significant 408 DEGs from the dataset based on p-values and logFC values. Using protein network analysis, we found the genes UBC, HSP90AB1, HSPH1, HSPA1B, HSPA1L, HSPA6, HSPD1, DNAJB1, HSPE1, DNAJC10, BAG3, and DNAJC7 had higher node degree distributio …
We screened the most significant 408 DEGs from the dataset based on p-values and logFC values. Using protein network analysis, we fou …
Residue interaction networks of K-Ras protein with water molecules identifies the potential role of switch II and P-loop.
Kumar SU, Priya Doss CG. Kumar SU, et al. Comput Biol Med. 2021 Aug;135:104597. doi: 10.1016/j.compbiomed.2021.104597. Epub 2021 Jun 23. Comput Biol Med. 2021. PMID: 34237589
The DynaMine prediction calculated the NMR S(2) value for the frequently mutated positions G12, G13, and Q61 showing a minor shift in flexibility, which make up the P-Loop and switch II of the K-Ras protein. This flexibility shift can account for changes in conformational …
The DynaMine prediction calculated the NMR S(2) value for the frequently mutated positions G12, G13, and Q61 showing a minor shift in flexib …
Computational validation of ABCB1 gene polymorphism and its effect on tacrolimus dose concentration/levels in renal transplant individuals of South India.
Mallina H, Elumalai R, F D Paul S, George Priya Doss C, Udhaya Kumar S, Ramanathan G. Mallina H, et al. Among authors: udhaya kumar s. Comput Biol Med. 2021 Dec;139:104971. doi: 10.1016/j.compbiomed.2021.104971. Epub 2021 Oct 23. Comput Biol Med. 2021. PMID: 34735949

Fisher's exact test and Chi-square analysis were performed to analyze the data, where p < 0.05 was considered statistically significant. In addition, we implemented bioinformatics studies on ABCB1 protein to determine the mutation's effect sequentially and structurally.

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Fisher's exact test and Chi-square analysis were performed to analyze the data, where p < 0.05 was considered statistically signif

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Molecular dynamics, residue network analysis, and cross-correlation matrix to characterize the deleterious missense mutations in GALE causing galactosemia III.
Kumar SU, Sankar S, Kumar DT, Younes S, Younes N, Siva R, Doss CGP, Zayed H. Kumar SU, et al. Cell Biochem Biophys. 2021 Jun;79(2):201-219. doi: 10.1007/s12013-020-00960-z. Epub 2021 Feb 8. Cell Biochem Biophys. 2021. PMID: 33555556
We applied a systematic computational prediction pipeline, including pathogenicity, stability, biochemical, conservational, protein residue contacts, and structural analysis, to predict the pathogenicity of these mutations. We found three mutations (p.K161N, p.R239W …
We applied a systematic computational prediction pipeline, including pathogenicity, stability, biochemical, conservational, protein residue …
Analysis of Differentially Expressed Genes and Molecular Pathways in Familial Hypercholesterolemia Involved in Atherosclerosis: A Systematic and Bioinformatics Approach.
Udhaya Kumar S, Thirumal Kumar D, Bithia R, Sankar S, Magesh R, Sidenna M, George Priya Doss C, Zayed H. Udhaya Kumar S, et al. Front Genet. 2020 Jul 15;11:734. doi: 10.3389/fgene.2020.00734. eCollection 2020. Front Genet. 2020. PMID: 32760426 Free PMC article.

The identified DEGs were subjected to the DAVID v6.8 webserver and ClueGo/CluePedia for functional annotation, such as gene ontology (GO) and enriched molecular pathway analysis of DEGs. Results: We investigated the top 250 significant DEGs (p-value < 0.05; fold two cha

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The identified DEGs were subjected to the DAVID v6.8 webserver and ClueGo/CluePedia for functional annotation, such as gene ontology (GO) an …