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Page 1
Efanesoctocog Alfa Prophylaxis for Patients with Severe Hemophilia A.
von Drygalski A, Chowdary P, Kulkarni R, Susen S, Konkle BA, Oldenburg J, Matino D, Klamroth R, Weyand AC, Jimenez-Yuste V, Nogami K, Poloskey S, Winding B, Willemze A, Knobe K; XTEND-1 Trial Group. von Drygalski A, et al. N Engl J Med. 2023 Jan 26;388(4):310-318. doi: 10.1056/NEJMoa2209226. N Engl J Med. 2023. PMID: 36720133 Clinical Trial.
The mean annualized bleeding rate decreased from 2.96 (95% CI, 2.00 to 4.37) to 0.69 (95% CI, 0.43 to 1.11), a finding that showed superiority over prestudy factor VIII prophylaxis (P<0.001). A total of 26 patients were enrolled in group B. In the overall population, ne …
The mean annualized bleeding rate decreased from 2.96 (95% CI, 2.00 to 4.37) to 0.69 (95% CI, 0.43 to 1.11), a finding that showed superiori …
Phase 1-2 Trial of AAVS3 Gene Therapy in Patients with Hemophilia B.
Chowdary P, Shapiro S, Makris M, Evans G, Boyce S, Talks K, Dolan G, Reiss U, Phillips M, Riddell A, Peralta MR, Quaye M, Patch DW, Tuddenham E, Dane A, Watissée M, Long A, Nathwani A. Chowdary P, et al. N Engl J Med. 2022 Jul 21;387(3):237-247. doi: 10.1056/NEJMoa2119913. N Engl J Med. 2022. PMID: 35857660 Free article. Clinical Trial.
Macrophage-mediated PDGF Activation Correlates With Regenerative Outcomes Following Musculoskeletal Trauma.
Chowdary AR, Maerz T, Henn D, Hankenson KD, Pagani CA, Marini S, Gallagher K, Aguilar CA, Tower RJ, Levi B. Chowdary AR, et al. Ann Surg. 2023 Aug 1;278(2):e349-e359. doi: 10.1097/SLA.0000000000005704. Epub 2022 Sep 15. Ann Surg. 2023. PMID: 36111847
METHODS: Mouse single-cell RNA sequencing data before and after injury were assembled from models of musculoskeletal injury, including regenerative and fibrotic mouse volumetric muscle loss (VML), regenerative digit tip amputation, and fibrotic heterotopic ossification. R …
METHODS: Mouse single-cell RNA sequencing data before and after injury were assembled from models of musculoskeletal injury, including regen …
Mechanism of monofunctional and bifunctional alkylation of DNA by mitomycin C.
Tomasz M, Chawla AK, Lipman R. Tomasz M, et al. Biochemistry. 1988 May 3;27(9):3182-7. doi: 10.1021/bi00409a009. Biochemistry. 1988. PMID: 3134045
The relative amounts of monofunctional and bifunctional alkylation products of DNA with mitomycin C (MC) depend on whether one or both masked alkylating functions of MC are activated reductively; adduct 8 is the result of one function and adducts 7 and 9, formed as a pair, are th …
The relative amounts of monofunctional and bifunctional alkylation products of DNA with mitomycin C (MC) depend on whether one or both maske …
Global coagulation assays in hemophilia A: A comparison to conventional assays.
Aghighi S, Riddell A, Lee CA, Brown SA, Tuddenham E, Chowdary P. Aghighi S, et al. Res Pract Thromb Haemost. 2019 Dec 29;4(2):298-308. doi: 10.1002/rth2.12295. eCollection 2020 Feb. Res Pract Thromb Haemost. 2019. PMID: 32110761 Free PMC article.

The MaxVel also strongly correlated with factor VIII (FVIII) levels of patients with HA (r = .805, P < .0001). CTI improved the sensitivity of TGA, providing more accurate results. ...APTT clot waveform analysis minimum value of first derivative (Min1) and minimu

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The MaxVel also strongly correlated with factor VIII (FVIII) levels of patients with HA (r = .805, P < .0001). CTI improved

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A mitomycin-N6-deoxyadenosine adduct isolated from DNA.
Palom Y, Lipman R, Musser SM, Tomasz M. Palom Y, et al. Chem Res Toxicol. 1998 Mar;11(3):203-10. doi: 10.1021/tx970205u. Chem Res Toxicol. 1998. PMID: 9544618
However, the HPLC elution time of 8 coincides with that of a major, unknown MC adduct detected previously in mouse mammary tumor cells treated with radiolabeled MC [Bizanek, R., Chowdary, D., Arai, H., Kasai, M., Hughes, C. S., Sartorelli, A. C., Rockwell, …
However, the HPLC elution time of 8 coincides with that of a major, unknown MC adduct detected previously in mouse mammary tumor cells treat …
Vegetation health conditions assessment and mapping using AVIRIS-NG hyperspectral and field spectroscopy data for -environmental impact assessment in coal mining sites.
Kayet N, Pathak K, Singh CP, Chowdary VM, Bhattacharya BK, Kumar D, Kumar S, Shaik I. Kayet N, et al. Ecotoxicol Environ Saf. 2022 Jul 1;239:113650. doi: 10.1016/j.ecoenv.2022.113650. Epub 2022 May 20. Ecotoxicol Environ Saf. 2022. PMID: 35605326 Free article.
We have used thirty narrow banded VIs based on the statistical measurement for suitable VIs identification. The highest Pearson's r, R(2), lowest RMSE, and P values indices have been used for VIs combined pixels analysis. ...It is also seen that there …
We have used thirty narrow banded VIs based on the statistical measurement for suitable VIs identification. The highest Pearson's …
Investigating the relationship between the HJHS and HAL in routine clinical practice: A retrospective review.
McLaughlin P, Morris R, Chowdary P. McLaughlin P, et al. Haemophilia. 2018 Nov;24(6):988-994. doi: 10.1111/hae.13614. Epub 2018 Oct 8. Haemophilia. 2018. PMID: 30295404

Similarly, median total HAL score was 80 with decreased function associated with increasing age: 18-30 years-90.4, 31-59 years-71.7, 51-73 years-49.5. Median Total HJHS and HAL demonstrated strong correlation (r(s ) = 0.66, P < 0.01). Moderate-to-strong co

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Similarly, median total HAL score was 80 with decreased function associated with increasing age: 18-30 years-90.4, 31-59 years-71.7, 51-73 y …
18 results