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Page 1
At law. Transferring the ethical hot potato.
Annas GJ. Annas GJ. Hastings Cent Rep. 1987 Feb;17(1):20-1. Hastings Cent Rep. 1987. PMID: 3557940
Annas applauds the reversal on appeal of three court decisions in which trial court judges sided with hospitals that refused to accede to the wishes of nonterminally ill patients to reject life-sustaining treatment. The appellate decisions he discusses are Bartling v. Supe …
Annas applauds the reversal on appeal of three court decisions in which trial court judges sided with hospitals that refused to accede to th …
Discovery of bicyclic inhibitors against menaquinone biosynthesis.
Choi SR, Larson MA, Hinrichs SH, Bartling AM, Frandsen J, Narayanasamy P. Choi SR, et al. Future Med Chem. 2016 Jan;8(1):11-6. doi: 10.4155/fmc.15.168. Future Med Chem. 2016. PMID: 26699277 Free PMC article.
CONCLUSION: Nontraditional bicyclic inhibitors, compounds 1 and 2 could serve as lead compounds for the development of an antimicrobial agent, with activities against M. tuberculosis and methicillin-resistant S. aureus....
CONCLUSION: Nontraditional bicyclic inhibitors, compounds 1 and 2 could serve as lead compounds for the development of an antimicrobial agen …
Severe chronic bronchitis in advanced emphysema increases mortality and hospitalizations.
Kim V, Sternberg AL, Washko G, Make BJ, Han MK, Martinez F, Criner GJ; National Emphysema Treatment Trial Research Group. Kim V, et al. COPD. 2013 Dec;10(6):667-78. doi: 10.3109/15412555.2013.827166. Epub 2013 Aug 26. COPD. 2013. PMID: 23978192 Clinical Trial.
Lung function and SGRQ scores over time were compared between groups. RESULTS: The CB+(N = 234; 38%) and CB- groups(N = 376; 62%) had similar survival (median 60.8 versus 65.7 months, p = 0.19) and time to hospitalization (median 26.9 versus 24.9 months, p …
Lung function and SGRQ scores over time were compared between groups. RESULTS: The CB+(N = 234; 38%) and CB- groups(N = 376; 6 …
Sex differences in severe pulmonary emphysema.
Martinez FJ, Curtis JL, Sciurba F, Mumford J, Giardino ND, Weinmann G, Kazerooni E, Murray S, Criner GJ, Sin DD, Hogg J, Ries AL, Han M, Fishman AP, Make B, Hoffman EA, Mohsenifar Z, Wise R; National Emphysema Treatment Trial Research Group. Martinez FJ, et al. Am J Respir Crit Care Med. 2007 Aug 1;176(3):243-52. doi: 10.1164/rccm.200606-828OC. Epub 2007 Apr 12. Am J Respir Crit Care Med. 2007. PMID: 17431226 Free PMC article. Clinical Trial.
MEASUREMENTS AND MAIN RESULTS: Detailed clinical, physiological, and radiological assessment, including quantitation of emphysema severity and distribution from helical chest computed tomography, was completed. In a subgroup (n = 101), airway size and thickness was determi …
MEASUREMENTS AND MAIN RESULTS: Detailed clinical, physiological, and radiological assessment, including quantitation of emphysema severity a …
Effects of pH on the potassium current in rabbit corneal epithelial cells.
Rich A, Bartling C, Farrugia G, Rae JL. Rich A, et al. Am J Physiol. 1997 Feb;272(2 Pt 1):C744-53. doi: 10.1152/ajpcell.1997.272.2.C744. Am J Physiol. 1997. PMID: 9124319
Bath perfusion with pH 6.00 Ringer solution after standard Ringer solution (pH 7.35) increased outward K+-selective current (I(K)) from 120 +/- 29 to 312 +/- 64 pA during a step depolarization to +50 mV and hyperpolarized the resting membrane potential (Em) from -52 +/- 5 to -62 …
Bath perfusion with pH 6.00 Ringer solution after standard Ringer solution (pH 7.35) increased outward K+-selective current (I(K)) from 120 …
Predictors of mortality in patients with emphysema and severe airflow obstruction.
Martinez FJ, Foster G, Curtis JL, Criner G, Weinmann G, Fishman A, DeCamp MM, Benditt J, Sciurba F, Make B, Mohsenifar Z, Diaz P, Hoffman E, Wise R; NETT Research Group. Martinez FJ, et al. Am J Respir Crit Care Med. 2006 Jun 15;173(12):1326-34. doi: 10.1164/rccm.200510-1677OC. Epub 2006 Mar 16. Am J Respir Crit Care Med. 2006. PMID: 16543549 Free PMC article. Clinical Trial.
RESULTS: Overall, high mortality was seen in this cohort (12.7 deaths per 100 person-years; 292 total deaths). In multivariate analyses, increasing age (p=0.001), oxygen utilization (p=0.04), lower total lung capacity % predicted (p=0.05), higher residual vol …
RESULTS: Overall, high mortality was seen in this cohort (12.7 deaths per 100 person-years; 292 total deaths). In multivariate analyses, inc …
Changes in arterial oxygenation and self-reported oxygen use after lung volume reduction surgery.
Snyder ML, Goss CH, Neradilek B, Polissar NL, Mosenifar Z, Wise RA, Fishman AP, Benditt JO; National Emphysema Treatment Trial Research Group. Snyder ML, et al. Am J Respir Crit Care Med. 2008 Aug 15;178(4):339-45. doi: 10.1164/rccm.200712-1826OC. Epub 2008 Jun 5. Am J Respir Crit Care Med. 2008. PMID: 18535254 Free PMC article. Clinical Trial.

MEASUREMENTS AND MAIN RESULTS: Pa(O(2)) breathing room air was equal in medical and surgical subjects at baseline (64.8 vs. 65.0 mm Hg, P = not significant), but lower in medical subjects at 6 months (63.6 vs. 70.0 mm Hg, P < 0.001), 12 months (63.9 vs. 68.7 mm H

…
MEASUREMENTS AND MAIN RESULTS: Pa(O(2)) breathing room air was equal in medical and surgical subjects at baseline (64.8 vs. 65.0 mm Hg, P …
Prevalence and clinical correlates of bronchoreversibility in severe emphysema.
Han MK, Wise R, Mumford J, Sciurba F, Criner GJ, Curtis JL, Murray S, Sternberg A, Weinman G, Kazerooni E, Fishman AP, Make B, Hoffman EA, Mosenifar Z, Martinez FJ; NETT Research Group. Han MK, et al. Eur Respir J. 2010 May;35(5):1048-56. doi: 10.1183/09031936.00052509. Epub 2009 Nov 19. Eur Respir J. 2010. PMID: 19926748 Free article. Clinical Trial.
They were also characterised by measures of symptoms, quality of life and quantitative measures of emphysema by computed tomography. Mean baseline forced expiratory volume in 1 s (FEV(1)) in this patient population is 24% predicted. 22.2% of patients demonstrated bronchore …
They were also characterised by measures of symptoms, quality of life and quantitative measures of emphysema by computed tomography. Mean ba …
Physiological and computed tomographic predictors of outcome from lung volume reduction surgery.
Washko GR, Martinez FJ, Hoffman EA, Loring SH, Estépar RS, Diaz AA, Sciurba FC, Silverman EK, Han MK, Decamp M, Reilly JJ; National Emphysema Treatment Trial Research Group. Washko GR, et al. Am J Respir Crit Care Med. 2010 Mar 1;181(5):494-500. doi: 10.1164/rccm.200906-0911OC. Epub 2009 Dec 3. Am J Respir Crit Care Med. 2010. PMID: 19965810 Free PMC article.
MEASUREMENTS AND MAIN RESULTS: Physiological measures of lung elastic recoil and inspiratory resistance were not correlated with improvement in either the FEV(1) (R = -0.03, P = 0.78 and R = -0.17, P = 0.16, respectively) or maximal exercise capacity (R = -0.02, …
MEASUREMENTS AND MAIN RESULTS: Physiological measures of lung elastic recoil and inspiratory resistance were not correlated with improvement …
41 results