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Page 1
Serum cortisol and outcome of ischemic brain infarction.
Murros K, Fogelholm R, Kettunen S, Vuorela AL. Murros K, et al. J Neurol Sci. 1993 May;116(1):12-7. doi: 10.1016/0022-510x(93)90083-b. J Neurol Sci. 1993. PMID: 8509800
Serum cortisol values predicted the stroke outcome. Both the 7 a.m. and the 7 p.m. values in the initial and 1-week samples correlated positively with the severity of hemiparesis on the corresponding days. The 7 p.m. values predicted better than …
Serum cortisol values predicted the stroke outcome. Both the 7 a.m. and the 7 p.m. values in the initial and 1-week sam …
Metabolism and Mass Balance of the Novel Nonsteroidal Androgen Receptor Inhibitor Darolutamide in Humans.
Taavitsainen P, Prien O, Kähkönen M, Niehues M, Korjamo T, Denner K, Nykänen P, Vuorela A, Jungmann NA, von Bühler CJ, Koskinen M, Zurth C, Gieschen H. Taavitsainen P, et al. Drug Metab Dispos. 2021 Jun;49(6):420-433. doi: 10.1124/dmd.120.000309. Epub 2021 Mar 30. Drug Metab Dispos. 2021. PMID: 33785516 Clinical Trial.
Aside from darolutamide, the most prominent metabolites in urine were O-glucoronide (M-7a/b) and N-glucuronide (M-15a/b), as well as pyrazole sulfates (M-29, M-24) and glucuronides (M-21, M-22) resulting from oxidative cleavage of the par …
Aside from darolutamide, the most prominent metabolites in urine were O-glucoronide (M-7a/b) and N-glucuronide (M-15a/b), as w …
Enhanced influenza A H1N1 T cell epitope recognition and cross-reactivity to protein-O-mannosyltransferase 1 in Pandemrix-associated narcolepsy type 1.
Vuorela A, Freitag TL, Leskinen K, Pessa H, Härkönen T, Stracenski I, Kirjavainen T, Olsen P, Saarenpää-Heikkilä O, Ilonen J, Knip M, Vaheri A, Partinen M, Saavalainen P, Meri S, Vaarala O. Vuorela A, et al. Nat Commun. 2021 Apr 16;12(1):2283. doi: 10.1038/s41467-021-22637-8. Nat Commun. 2021. PMID: 33863907 Free PMC article.
An ethnobotanical survey and antifungal activity of Piper guineense used for the treatment of fungal infections in West-African traditional medicine.
Mgbeahuruike EE, Holm Y, Vuorela H, Amandikwa C, Fyhrquist P. Mgbeahuruike EE, et al. J Ethnopharmacol. 2019 Jan 30;229:157-166. doi: 10.1016/j.jep.2018.10.005. Epub 2018 Oct 15. J Ethnopharmacol. 2019. PMID: 30336302
AIM OF STUDY: The scarce number of previous studies on the documentation of the traditional uses of P. guineense extracts for the treatment of fungal infections in Nigeria prompted this survey. ...In accordance with these recorded traditional uses, we found that extracts o …
AIM OF STUDY: The scarce number of previous studies on the documentation of the traditional uses of P. guineense extracts for the tre …
Impairment of captopril bioavailability by concomitant food and antacid intake.
Mäntylä R, Männistö PT, Vuorela A, Sundberg S, Ottoila P. Mäntylä R, et al. Int J Clin Pharmacol Ther Toxicol. 1984 Nov;22(11):626-9. Int J Clin Pharmacol Ther Toxicol. 1984. PMID: 6389377
The peak captopril concentrations attained were 701 +/- 81 ng/ml (mean +/- s.e.m.) after fasting, 351 +/- 56 ng/ml with an antacid (p less than 0.05) and 140 +/- 14 ng/ml after a meal (p less than 0.01). The peak concentrations were reached in 0.5, 0.9 and 1. …
The peak captopril concentrations attained were 701 +/- 81 ng/ml (mean +/- s.e.m.) after fasting, 351 +/- 56 ng/ml with an antacid ( …
Change in prevalence of overweight and obesity in Finnish children - comparison between 1974 and 2001.
Vuorela N, Saha MT, Salo MK. Vuorela N, et al. Acta Paediatr. 2011 Jan;100(1):109-15. doi: 10.1111/j.1651-2227.2010.01980.x. Epub 2010 Aug 26. Acta Paediatr. 2011. PMID: 20712840
RESULTS: The combined prevalence of overweight and obesity decreased significantly in 2-year-old boys (p = 0.009) and girls (p = 0.002) from 1974 to 2001. Insignificant fluctuation was seen in 5- and 7-year-old children. Both the prevalence of obesity and the combin …
RESULTS: The combined prevalence of overweight and obesity decreased significantly in 2-year-old boys (p = 0.009) and girls (p …
Corn mint (Mentha arvensis) extract diminishes acute Chlamydia pneumoniae infection in vitro and in vivo.
Salin O, Törmäkangas L, Leinonen M, Saario E, Hagström M, Ketola RA, Saikku P, Vuorela H, Vuorela PM. Salin O, et al. J Agric Food Chem. 2011 Dec 28;59(24):12836-42. doi: 10.1021/jf2032473. Epub 2011 Nov 22. J Agric Food Chem. 2011. PMID: 22073967
Linarin completely inhibited the growth at 100 muM. Inbred C57BL/6J mice were inoculated with C. pneumoniae K7. M. arvensis extract was given intraperitoneally once daily for 3 days prior to inoculation and continued for 10 days postinfection. The extract was able to dimin …
Linarin completely inhibited the growth at 100 muM. Inbred C57BL/6J mice were inoculated with C. pneumoniae K7. M. arvensis extract w …
Development and validation of a near-infrared method for the quantitation of caffeine in intact single tablets.
Laasonen M, Harmia-Pulkkinen T, Simard C, Räsänen M, Vuorela H. Laasonen M, et al. Anal Chem. 2003 Feb 15;75(4):754-60. doi: 10.1021/ac026262w. Anal Chem. 2003. PMID: 12622363
A near-infrared spectroscopic method was developed and validated for determining the caffeine concentration of single and intact tablets in a Finnish pharmaceutical product containing 58.82% (m/m) caffeine.The spectral region of interest contained a total of 474 dat …
A near-infrared spectroscopic method was developed and validated for determining the caffeine concentration of single and intact tablets in …
Terminalia laxiflora and Terminalia brownii contain a broad spectrum of antimycobacterial compounds including ellagitannins, ellagic acid derivatives, triterpenes, fatty acids and fatty alcohols.
Salih EYA, Julkunen-Tiitto R, Lampi AM, Kanninen M, Luukkanen O, Sipi M, Lehtonen M, Vuorela H, Fyhrquist P. Salih EYA, et al. J Ethnopharmacol. 2018 Dec 5;227:82-96. doi: 10.1016/j.jep.2018.04.030. Epub 2018 May 4. J Ethnopharmacol. 2018. PMID: 29733942
Of the listed compounds, friedelin, triacontanol and sitostenone gave a MIC of 250 g/ml against M. smegmatis, whereas stigmasterol and beta-sitosterol gave MIC values of 500 g/ml. ...
Of the listed compounds, friedelin, triacontanol and sitostenone gave a MIC of 250 g/ml against M. smegmatis, whereas stigmasterol an …
Spontaneous somatic embryogenesis and plant regeneration from root cultures of Peucedanum palustre.
Vuorela P, Oksman-Caldentey KM, Lipponen J, Hiltunen R. Vuorela P, et al. Plant Cell Rep. 1993 May;12(7-8):453-6. doi: 10.1007/BF00234711. Plant Cell Rep. 1993. PMID: 24197351
Callus formation occurred on the root cultures and showed spontaneous embryogenic capability on B5 basal medium supplemented with a low concentration of indoleacetic acid (5.5 10(-7) M). 2,4-Dichlorophenoxyacetic acid was not needed for the initiation of embryogenesis. ...
Callus formation occurred on the root cultures and showed spontaneous embryogenic capability on B5 basal medium supplemented with a low conc …