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Efficacy and Safety of Degludec versus Glargine in Type 2 Diabetes.
Marso SP, McGuire DK, Zinman B, Poulter NR, Emerson SS, Pieber TR, Pratley RE, Haahr PM, Lange M, Brown-Frandsen K, Moses A, Skibsted S, Kvist K, Buse JB; DEVOTE Study Group. Marso SP, et al. N Engl J Med. 2017 Aug 24;377(8):723-732. doi: 10.1056/NEJMoa1615692. Epub 2017 Jun 12. N Engl J Med. 2017. PMID: 28605603 Free PMC article. Clinical Trial.
The primary outcome occurred in 325 patients (8.5%) in the degludec group and in 356 (9.3%) in the glargine group (hazard ratio, 0.91; 95% confidence interval, 0.78 to 1.06; P<0.001 for noninferiority). At 24 months, the mean glycated hemoglobin level was 7.51.2% in eac …
The primary outcome occurred in 325 patients (8.5%) in the degludec group and in 356 (9.3%) in the glargine group (hazard ratio, 0.91; 95% c …
Incidence, Clinical Characteristics and Management of Inflammatory Bowel Disease in Spain: Large-Scale Epidemiological Study.
Chaparro M, Garre A, Núñez Ortiz A, Diz-Lois Palomares MT, Rodríguez C, Riestra S, Vela M, Benítez JM, Fernández Salgado E, Sánchez Rodríguez E, Hernández V, Ferreiro-Iglesias R, Ponferrada Díaz Á, Barrio J, Huguet JM, Sicilia B, Martín-Arranz MD, Calvet X, Ginard D, Alonso-Abreu I, Fernández-Salazar L, Varela Trastoy P, Rivero M, Vera-Mendoza I, Vega P, Navarro P, Sierra M, Cabriada JL, Aguas M, Vicente R, Navarro-Llavat M, Echarri A, Gomollón F, Guerra Del Río E, Piñero C, Casanova MJ, Spicakova K, Ortiz de Zarate J, Torrella Cortés E, Gutiérrez A, Alonso-Galán H, Hernández-Martínez Á, Marrero JM, Lorente Poyatos R, Calafat M, Martí Romero L, Robledo P, Bosch O, Jiménez N, Esteve Comas M, Duque JM, Fuentes Coronel AM, Josefa Sampedro M, Sesé Abizanda E, Herreros Martínez B, Pozzati L, Fernández Rosáenz H, Crespo Suarez B, López Serrano P, Lucendo AJ, Muñoz Vicente M, Bermejo F, Ramírez Palanca JJ, Menacho M, Carmona A, Camargo R, Torra Alsina S, Maroto N, Nerín de la Puerta J, Castro E, Marín-Jiménez I, Botella B, Sapiña A, Cruz N, Forcelledo JLF, Bouhmidi A, Castaño-Milla C, Opio V, Nicolás I, Kutz M, Abraldes Bechiarelli A, Gordillo J, Ber Y, Torres Domínguez Y, Novella Durán … See abstract for full author list ➔ Chaparro M, et al. J Clin Med. 2021 Jun 29;10(13):2885. doi: 10.3390/jcm10132885. J Clin Med. 2021. PMID: 34209680 Free PMC article.
In total, 28% of patients were hospitalized (35% CD and 22% UC patients, p < 0.01). (4) Conclusion: The incidence of IBD in Spain is rather high and similar to that reported in Northern Europe. ...

In total, 28% of patients were hospitalized (35% CD and 22% UC patients, p < 0.01). (4) Conclusion: The incidence of IBD in Spain

…
Mycobacterium manresensis induces trained immunity in vitro.
de Homdedeu M, Sanchez-Moral L, Violán C, Ràfols N, Ouchi D, Martín B, Peinado MA, Rodríguez-Cortés A, Arch-Sisquella M, Perez-Zsolt D, Muñoz-Basagoiti J, Izquierdo-Useros N, Salvador B, Matllo J, López-Serrano S, Segalés J, Vilaplana C, Torán-Monserrat P, Morros R, Monfà R, Sarrias MR, Cardona PJ. de Homdedeu M, et al. iScience. 2023 Jun 16;26(6):106873. doi: 10.1016/j.isci.2023.106873. Epub 2023 May 13. iScience. 2023. PMID: 37250788 Free PMC article.
No significant differences in monocyte inflammatory responses or the incidence of SARS-CoV-2 infection were found between the groups, although NR modified the profile of circulating immune cell populations. Our results show that M. manresensis induces trained immunity in v …
No significant differences in monocyte inflammatory responses or the incidence of SARS-CoV-2 infection were found between the groups, althou …
Comparison of carbon content between plantation and natural regeneration seedlings in Durango, Mexico.
Soto-Cervantes JA, Corral-Rivas JJ, Domínguez-Calleros PA, López-Serrano PM, Montiel-Antuna E, García-Montiel E, Pérez-Luna A. Soto-Cervantes JA, et al. PeerJ. 2023 Feb 9;11:e14774. doi: 10.7717/peerj.14774. eCollection 2023. PeerJ. 2023. PMID: 36788810 Free PMC article.
At each plot, the diameter at the base (cm) and height (m) of all seedlings were measured using a Vernier and tape measure, and a seedling was destructively sampled collecting one cross-section at the base of the stump. ...The response variables were evaluated using mixed- …
At each plot, the diameter at the base (cm) and height (m) of all seedlings were measured using a Vernier and tape measure, and a see …
The voltage-sensitive cardiac M(2) muscarinic receptor modulates the inward rectification of the G protein-coupled, ACh-gated K(+) current.
Salazar-Fajardo PD, Aréchiga-Figueroa IA, López-Serrano AL, Rodriguez-Elias JC, Alamilla J, Sánchez-Chapula JA, Tristani-Firouzi M, Navarro-Polanco RA, Moreno-Galindo EG. Salazar-Fajardo PD, et al. Pflugers Arch. 2018 Dec;470(12):1765-1776. doi: 10.1007/s00424-018-2196-y. Epub 2018 Aug 28. Pflugers Arch. 2018. PMID: 30155776
These observations indicate that the time- and concentration-dependent rectification mechanism is an intrinsic property of the receptor, M(2)R; consistent with our previous work demonstrating that voltage-dependent conformational changes in the M(2)R alter the recep …
These observations indicate that the time- and concentration-dependent rectification mechanism is an intrinsic property of the receptor, …
Metal-only Lewis Pairs of Rhodium with s, p and d-Block Metals.
Bajo S, Alférez MG, Alcaide MM, López-Serrano J, Campos J. Bajo S, et al. Chemistry. 2020 Dec 15;26(70):16833-16845. doi: 10.1002/chem.202003167. Epub 2020 Nov 9. Chemistry. 2020. PMID: 32722855 Free PMC article.
Here we report a family of MOLPs constructed around the Rh(I) precursor [(eta(5) -C(5) Me(5) )Rh(PMe(3) )(2) ] (1) with a series of s, p and d-block metals, mostly from the main group elements, and investigate their bonding by computational means. Among the new MOLPs, we h …
Here we report a family of MOLPs constructed around the Rh(I) precursor [(eta(5) -C(5) Me(5) )Rh(PMe(3) )(2) ] (1) with a series of s, p …
Transpiration Dynamics of Esparto Grass (Macrochloa tenacissima (L.) Kunth) in a Semi-Arid Mediterranean Climate: Unraveling the Impacts of Pine Competition.
Pérez-Anta I, Rubio E, López-Serrano FR, Garcés D, Andrés-Abellán M, Picazo M, Chebbi W, Arquero R, García-Morote FA. Pérez-Anta I, et al. Plants (Basel). 2024 Feb 27;13(5):661. doi: 10.3390/plants13050661. Plants (Basel). 2024. PMID: 38475507 Free PMC article.
Macrochloa tenacissima (M. tenacissima), or esparto, is a perennial tussock grass that coexists with Pinus halepensis (P. halepensis) in semi-arid Mediterranean woodlands. ...The relationship between transpiration and competition was conducted in open and closed …
Macrochloa tenacissima (M. tenacissima), or esparto, is a perennial tussock grass that coexists with Pinus halepensis (P. hale …
Antitumor Necrosis Factor Agents to Treat Endoscopic Postoperative Recurrence of Crohn's Disease: A Nationwide Study With Propensity-Matched Score Analysis.
Cañete F, Mañosa M, Pérez-Martínez I, Barreiro-de Acosta M, González-Sueyro RC, Nos P, Iglesias-Flores E, Gutiérrez A, Bujanda L, Gordillo J, Ríos León R, Casanova MJ, Villoria A, Rodríguez-Lago I, López Serrano P, García-Herola A, Ramírez-de la Piscina P, Navarro-Llavat M, Taxonera C, Barrio J, Ramos L, Navarro P, Benítez-Leiva O, Calafat M, Domènech E; INFLIRECU study. Cañete F, et al. Clin Transl Gastroenterol. 2020 Aug;11(8):e00218. doi: 10.14309/ctg.0000000000000218. Clin Transl Gastroenterol. 2020. PMID: 32955190 Free PMC article.

Concomitant use of thiopurines and treatment with infliximab were associated with endoscopic improvement (odds ratio [OR] 2.15, 95% confidence interval [CI] 1.04-4.46; P = 0.03, and OR 2.34, 95% CI 1.18-4.62; P < 0.01, respectively) and endoscopic remission (OR 3

…
Concomitant use of thiopurines and treatment with infliximab were associated with endoscopic improvement (odds ratio [OR] 2.15, 95% confiden …
[Effect of pentoxifylline on survival, cardiac function and both portal and systemic hemodynamics in advanced alcoholic cirrhosis--a randomized double-blind placebo-controlled trial].
Fernández-Rodríguez CM, Lledó JL, López-Serrano P, Gutiérrez ML, Alonso S, Pérez-Fernández MT, Fernández Gil M, Pazos R, Tolon R, Hernández T, Sanz P. Fernández-Rodríguez CM, et al. Rev Esp Enferm Dig. 2008 Aug;100(8):481-9. doi: 10.4321/s1130-01082008000800007. Rev Esp Enferm Dig. 2008. PMID: 18942901 Free article. Clinical Trial. Spanish.
The group on pentoxiphylline increased systemic vascular resistance and decreased cardiac indices (from 1,721 +/- 567 to 2,082 +/- 622 dyn.sec(-1) cm(-5) m(-2) and from 4.17 +/- 1.4 to 3.4 +/- 0.9 l.m(-2), p = 0.05). ...
The group on pentoxiphylline increased systemic vascular resistance and decreased cardiac indices (from 1,721 +/- 567 to 2,082 +/- 622 dyn.s …