Utilization of Carica papaya latex on coating of SPIONs for dye removal and drug delivery

Sci Rep. 2021 Dec 31;11(1):24511. doi: 10.1038/s41598-021-03328-2.

Abstract

Latex, a milky substance found in a variety of plants which is a natural source of biologically active compounds. In this study, Latex was collected from raw Carica papaya and was characterized using UV-Vis, FTIR and GC-MS analyses. Super Paramagnetic Iron Oxide Nanoparticles (SPIONs) were synthesized, coated with C. papaya latex (PL-Sp) and characterized using UV-Vis, FT-IR, SEM-EDX, XRD, VSM and Zeta potential analyses. SPIONs and latex coated SPIONs (PL-Sp) were used in batch adsorption study for effective removal of Methylene blue (MB) dye, where (PL-Sp) removed MB dye effectively. Further the PL-Sp was used to produce a nanoconjugate loaded with curcumin and it was characterized using UV-Vis spectrophotometer, FT-IR, SEM-EDX, XRD, VSM and Zeta potential. It showed a sustained drug release pattern and also found to have good antibacterial and anticancer activity.

MeSH terms

  • Carica / chemistry*
  • Chemical Phenomena
  • Coated Materials, Biocompatible / chemistry*
  • Coloring Agents / analysis
  • Coloring Agents / chemistry*
  • Drug Carriers*
  • Drug Compounding
  • Drug Delivery Systems
  • Latex / chemistry*
  • Magnetite Nanoparticles / chemistry*
  • Magnetite Nanoparticles / ultrastructure
  • Nanotechnology
  • Phytochemicals / chemistry*
  • Spectrum Analysis

Substances

  • Coated Materials, Biocompatible
  • Coloring Agents
  • Drug Carriers
  • Latex
  • Magnetite Nanoparticles
  • Phytochemicals