Ivacaftor decreases monocyte sensitivity to interferon-γ in people with cystic fibrosis

Katherine B Hisert; Timothy P Birkland; Kelly Q Schoenfelt; Matthew E Long; Brenda Grogan; Suzanne Carter; W Conrad Liles; Edward F McKone; Lev Becker; Anne M Manicone

doi:10.1183/23120541.00318-2019

Ivacaftor decreases monocyte sensitivity to interferon-γ in people with cystic fibrosis

ERJ Open Res. 2020 Apr 19;6(2):00318-2019. doi: 10.1183/23120541.00318-2019. eCollection 2020 Apr.

Authors

Affiliations

¹ Dept of Medicine, University of Washington, Seattle, WA, USA.
² Ben May Dept for Cancer Research, University of Chicago, Chicago, IL, USA.
³ Dept of Medicine, St Vincent's University Hospital, Dublin, Ireland.
⁴ These authors contributed equally.

Abstract

This study demonstrates that initiation of the CFTR modulator ivacaftor in people with cystic fibrosis and susceptible CFTR mutations causes an acute reduction in blood monocyte sensitivity to the key proinflammatory cytokine IFN-γ http://bit.ly/2TeI6LG.

Abstract

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