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2009 1
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2020 3
2021 1
2023 1
2024 1

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Page 1
BI-3406, a Potent and Selective SOS1-KRAS Interaction Inhibitor, Is Effective in KRAS-Driven Cancers through Combined MEK Inhibition.
Hofmann MH, Gmachl M, Ramharter J, Savarese F, Gerlach D, Marszalek JR, Sanderson MP, Kessler D, Trapani F, Arnhof H, Rumpel K, Botesteanu DA, Ettmayer P, Gerstberger T, Kofink C, Wunberg T, Zoephel A, Fu SC, Teh JL, Böttcher J, Pototschnig N, Schachinger F, Schipany K, Lieb S, Vellano CP, O'Connell JC, Mendes RL, Moll J, Petronczki M, Heffernan TP, Pearson M, McConnell DB, Kraut N. Hofmann MH, et al. Cancer Discov. 2021 Jan;11(1):142-157. doi: 10.1158/2159-8290.CD-20-0142. Epub 2020 Aug 19. Cancer Discov. 2021. PMID: 32816843 Free PMC article.
In-depth characterization of BI-3406 activity and identification of MEK inhibitors as effective combination partners provide an attractive therapeutic concept for the majority of KRAS-mutant cancers, including those fueled by the most prevalent mutant KRAS oncoproteins, G12D, G12 …
In-depth characterization of BI-3406 activity and identification of MEK inhibitors as effective combination partners provide an attractive t …
Predicting ligand interactions with ABC transporters in ADME.
Demel MA, Krämer O, Ettmayer P, Haaksma EE, Ecker GF. Demel MA, et al. Chem Biodivers. 2009 Nov;6(11):1960-9. doi: 10.1002/cbdv.200900138. Chem Biodivers. 2009. PMID: 19937827 Review.
ABC-type drug efflux pumps, e.g., ABCB1 (=P-glycoprotein, =MDR1), ABCC1 (=MRP1), and ABCG2 (=MXR, =BCRP), confer a multi-drug resistance (MDR) phenotype to cancer cells. ...
ABC-type drug efflux pumps, e.g., ABCB1 (=P-glycoprotein, =MDR1), ABCC1 (=MRP1), and ABCG2 (=MXR, =BCRP), confer a multi-drug resista …
Native Mass Spectrometry Can Effectively Predict PROTAC Efficacy.
Beveridge R, Kessler D, Rumpel K, Ettmayer P, Meinhart A, Clausen T. Beveridge R, et al. ACS Cent Sci. 2020 Jul 22;6(7):1223-1230. doi: 10.1021/acscentsci.0c00049. Epub 2020 Jul 6. ACS Cent Sci. 2020. PMID: 32724856 Free PMC article.
Radiographic angle width as predictor of clinical outcomes following regenerative periodontal therapy with enamel matrix derivative: a retrospective cohort study with a mean follow-up of at least 10 years.
Roccuzzo A, Ettmayer J, De Ry SP, Imber JC, Sculean A, Salvi GE. Roccuzzo A, et al. Quintessence Int. 2023 May 19;54(5):384-392. doi: 10.3290/j.qi.b3824933. Quintessence Int. 2023. PMID: 36661359

The mean PD change between T0 and T2 was 2.33 1.66 mm at teeth with a defect angle width < 20 degrees and 0.86 1.66 mm at teeth with a defect angle width > 30 degrees (P = .021). When the baseline radiographic angle width was < 20 degrees the probability of obtain

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The mean PD change between T0 and T2 was 2.33 1.66 mm at teeth with a defect angle width < 20 degrees and 0.86 1.66 mm at teeth with a de

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Selective and Potent CDK8/19 Inhibitors Enhance NK-Cell Activity and Promote Tumor Surveillance.
Hofmann MH, Mani R, Engelhardt H, Impagnatiello MA, Carotta S, Kerenyi M, Lorenzo-Herrero S, Böttcher J, Scharn D, Arnhof H, Zoephel A, Schnitzer R, Gerstberger T, Sanderson MP, Rajgolikar G, Goswami S, Vasu S, Ettmayer P, Gonzalez S, Pearson M, McConnell DB, Kraut N, Muthusamy N, Moll J. Hofmann MH, et al. Mol Cancer Ther. 2020 Apr;19(4):1018-1030. doi: 10.1158/1535-7163.MCT-19-0789. Epub 2020 Feb 5. Mol Cancer Ther. 2020. PMID: 32024684 Free PMC article.
Ensemble Rule-Based Classification of Substrates of the Human ABC-Transporter ABCB1 Using Simple Physicochemical Descriptors.
Demel MA, Kraemer O, Ettmayer P, Haaksma E, Ecker GF. Demel MA, et al. Mol Inform. 2010 Mar 15;29(3):233-42. doi: 10.1002/minf.200900079. Epub 2010 Mar 9. Mol Inform. 2010. PMID: 27462766
Within the last decades, the detailed knowledge on the impact of membrane bound drug efflux transporters of the ATP binding cassette (ABC) protein family on the pharmacological profile of drugs has enormously increased. Especially, ABCB1 (P-glycoprotein, P-gp, MDR1) …
Within the last decades, the detailed knowledge on the impact of membrane bound drug efflux transporters of the ATP binding cassette (ABC) p …
In-vitro effects of novel periodontal scalers with a planar ultrasonic piezoelectric transducer on periodontal biofilm removal, dentine surface roughness, and periodontal ligament fibroblasts adhesion.
Berto LA, Ettmayer JB, Stutzer D, Nietzsche S, Niederhauser T, Burger J, Sculean A, Eick S, Hofmann M. Berto LA, et al. Clin Oral Investig. 2024 May 3;28(5):294. doi: 10.1007/s00784-024-05671-w. Clin Oral Investig. 2024. PMID: 38698252

RESULTS: All tested instruments reduced the colony-forming unit (cfu) counts by about 3 to 4 log(10) and the biofilm quantity (each p < 0.01 vs. control), but with no statistically significant difference between the instrumented groups. ...The attachment of fibroblasts

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RESULTS: All tested instruments reduced the colony-forming unit (cfu) counts by about 3 to 4 log(10) and the biofilm quantity (each p …