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1983 1
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1993 1
1995 1
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2005 1
2006 1
2007 2
2008 2
2009 1
2010 4
2011 1
2012 3
2013 2
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Page 1
Human germline heterozygous gain-of-function STAT6 variants cause severe allergic disease.
Sharma M, Leung D, Momenilandi M, Jones LCW, Pacillo L, James AE, Murrell JR, Delafontaine S, Maimaris J, Vaseghi-Shanjani M, Del Bel KL, Lu HY, Chua GT, Di Cesare S, Fornes O, Liu Z, Di Matteo G, Fu MP, Amodio D, Tam IYS, Chan GSW, Sharma AA, Dalmann J, van der Lee R, Blanchard-Rohner G, Lin S, Philippot Q, Richmond PA, Lee JJ, Matthews A, Seear M, Turvey AK, Philips RL, Brown-Whitehorn TF, Gray CJ, Izumi K, Treat JR, Wood KH, Lack J, Khleborodova A, Niemela JE, Yang X, Liang R, Kui L, Wong CSM, Poon GWK, Hoischen A, van der Made CI, Yang J, Chan KW, Rosa Duque JSD, Lee PPW, Ho MHK, Chung BHY, Le HTM, Yang W, Rohani P, Fouladvand A, Rokni-Zadeh H, Changi-Ashtiani M, Miryounesi M, Puel A, Shahrooei M, Finocchi A, Rossi P, Rivalta B, Cifaldi C, Novelli A, Passarelli C, Arasi S, Bullens D, Sauer K, Claeys T, Biggs CM, Morris EC, Rosenzweig SD, O'Shea JJ, Wasserman WW, Bedford HM, van Karnebeek CDM, Palma P, Burns SO, Meyts I, Casanova JL, Lyons JJ, Parvaneh N, Nguyen ATV, Cancrini C, Heimall J, Ahmed H, McKinnon ML, Lau YL, Béziat V, Turvey SE. Sharma M, et al. J Exp Med. 2023 May 1;220(5):e20221755. doi: 10.1084/jem.20221755. Epub 2023 Mar 8. J Exp Med. 2023. PMID: 36884218 Free PMC article.
Treatment of Anal High-Grade Squamous Intraepithelial Lesions to Prevent Anal Cancer.
Palefsky JM, Lee JY, Jay N, Goldstone SE, Darragh TM, Dunlevy HA, Rosa-Cunha I, Arons A, Pugliese JC, Vena D, Sparano JA, Wilkin TJ, Bucher G, Stier EA, Tirado Gomez M, Flowers L, Barroso LF, Mitsuyasu RT, Lensing SY, Logan J, Aboulafia DM, Schouten JT, de la Ossa J, Levine R, Korman JD, Hagensee M, Atkinson TM, Einstein MH, Cracchiolo BM, Wiley D, Ellsworth GB, Brickman C, Berry-Lawhorn JM; ANCHOR Investigators Group. Palefsky JM, et al. N Engl J Med. 2022 Jun 16;386(24):2273-2282. doi: 10.1056/NEJMoa2201048. N Engl J Med. 2022. PMID: 35704479 Free PMC article. Clinical Trial.
The rate of progression to anal cancer was lower in the treatment group than in the active-monitoring group by 57% (95% CI, 6 to 80; P = 0.03 by log-rank test). CONCLUSIONS: Among participants with biopsy-proven anal HSIL, the risk of anal cancer was significantly lower wi …
The rate of progression to anal cancer was lower in the treatment group than in the active-monitoring group by 57% (95% CI, 6 to 80; P
Reactivity of Ir(I)-aminophosphane platforms towards oxidants.
Palmese M, Pérez-Torrente JJ, Passarelli V. Palmese M, et al. Dalton Trans. 2023 Oct 3;52(38):13689-13703. doi: 10.1039/d3dt02361c. Dalton Trans. 2023. PMID: 37706349
[Ir{kappa(3)C,P,P'-(SiNP-H)}(cod)] reacts with [FeCp(2)](+) (1 : 2) in acetonitrile affording [Ir{kappa(3)C,P,P'-(SiNP-H)}(CH(3)CN)(3)](2+) isolated as both the triflato and the hexafluorophosphato derivatives. Also, the reaction of [Ir{k …
[Ir{kappa(3)C,P,P'-(SiNP-H)}(cod)] reacts with [FeCp(2)](+) (1 : 2) in acetonitrile affording [Ir{kappa(3)C,P
Melanoma and immunotherapy bridge 2015 : Naples, Italy. 1-5 December 2015.
Nanda VGY, Peng W, Hwu P, Davies MA, Ciliberto G, Fattore L, Malpicci D, Aurisicchio L, Ascierto PA, Croce CM, Mancini R, Spranger S, Gajewski TF, Wang Y, Ferrone S, Vanpouille-Box C, Wennerberg E, Pilones KA, Formenti SC, Demaria S, Tang H, Wang Y, Fu YX, Dummer R, Puzanov I, Tarhini A, Chauvin JM, Pagliano O, Fourcade J, Sun Z, Wang H, Sanders C, Kirkwood JM, Chen THT, Maurer M, Korman AJ, Zarour HM, Stroncek DF, Huber V, Rivoltini L, Thurin M, Rau T, Lugli A, Pagès F, Camarero J, Sancho A, Jommi C, de Coaña YP, Wolodarski M, Yoshimoto Y, Gentilcore G, Poschke I, Masucci GV, Hansson J, Kiessling R, Scognamiglio G, Sabbatino F, Marino FZ, Anniciello AM, Cantile M, Cerrone M, Scala S, D’alterio C, Ianaro A, Cirin G, Liguori G, Bott G, Chapman PB, Robert C, Larkin J, Haanen JB, Ribas A, Hogg D, Hamid O, Testori A, Lorigan P, Sosman JA, Flaherty KT, Yue H, Coleman S, Caro I, Hauschild A, McArthur GA, Sznol M, Callahan MK, Kluger H, Postow MA, Gordan R, Segal NH, Rizvi NA, Lesokhin A, Atkins MB, Burke MM, Ralabate A, Rivera A, Kronenberg SA, Agunwamba B, Ruisi M, Horak C, Jiang J, Wolchok J, Ascierto PA, Liszkay G, Maio M, Mandalà M, Demidov L, Stoyakovskiy D, Thomas L, de la Cruz-Me… See abstract for full author list ➔ Nanda VGY, et al. J Transl Med. 2016 Jul 25;14(1):65. doi: 10.1186/s12967-016-0791-2. J Transl Med. 2016. PMID: 27461275 Free PMC article.
Balmanoukian, David R. Kaufman, Yufan Zhao, Janet Maleski, Lance Leopold, Tara C. Gangadhar O8 Primary analysis of MASTERKEY-265 phase 1b study of talimogene laherparepvec (T-VEC) and pembrolizumab (pembro) for unresectable stage IIIB-IV melanoma Reinhard Dummer, Georgina …
Balmanoukian, David R. Kaufman, Yufan Zhao, Janet Maleski, Lance Leopold, Tara C. Gangadhar O8 Primary analysis of MASTERKEY-265 phas …
Cyclometalated iridium complexes based on monodentate aminophosphanes.
Palmese M, Pérez-Torrente JJ, Passarelli V. Palmese M, et al. Dalton Trans. 2022 Aug 16;51(32):12334-12351. doi: 10.1039/d2dt02081e. Dalton Trans. 2022. PMID: 35904083
The straighforward formation of [IrH{kappa(2)C,P-SiMe(3)N(4-C(6)H(3)CH(3))PPh(2)}(cod)(CH(3)CN)](+) was observed when the reaction was monitored by NMR spectroscopy at 233 K, whereas a more complex reaction sequence was observed in the formation of [IrH{kappa …
The straighforward formation of [IrH{kappa(2)C,P-SiMe(3)N(4-C(6)H(3)CH(3))PPh(2)}(cod)(CH(3)CN)](+) was observed when t …
Divergence Between Clinical Trial Evidence and Actual Practice in Use of Dual Antiplatelet Therapy After Transient Ischemic Attack and Minor Stroke.
De Matteis E, De Santis F, Ornello R, Censori B, Puglisi V, Vinciguerra L, Giossi A, Di Viesti P, Inchingolo V, Fratta GM, Diomedi M, Bagnato MR, Cenciarelli S, Bedetti C, Padiglioni C, Tassinari T, Saia V, Russo A, Petruzzellis M, Mezzapesa DM, Caccamo M, Rinaldi G, Bavaro A, Paciaroni M, Mosconi MG, Foschi M, Querzani P, Muscia F, Gallo Cassarino S, Candelaresi P, De Mase A, Guarino M, Cupini LM, Sanzaro E, Zini A, La Spada S, Palmieri C, Sepe FN, Beretta S, Paci C, Caggia EA, De Angelis MV, Bonanni L, Volpi G, Tassi R, Pistoia F, Scoditti U, Tonon A, Viticchi G, Ruzza G, Nencini P, Cavallini A, Toni D, Ricci S, Sacco S; READAPT Study Group. De Matteis E, et al. Stroke. 2023 May;54(5):1172-1181. doi: 10.1161/STROKEAHA.122.041660. Epub 2023 Mar 23. Stroke. 2023. PMID: 36951052 Clinical Trial.
Cobalt-catalysed nucleophilic fluorination in organic carbonates.
García-Abellán S, Barrena-Espés D, Munarriz J, Passarelli V, Iglesias M. García-Abellán S, et al. Dalton Trans. 2023 Apr 4;52(14):4585-4594. doi: 10.1039/d3dt00731f. Dalton Trans. 2023. PMID: 36928731
The novel P-N ligand 1-((diphenylphosphaneyl)methyl)-1H-benzo-1,2,3-triazole (1), based on a benzotriazole scaffold, has been prepared. The reaction of 1 with [CoCp*(CH(3)CN)(3)][BF(4)](2) and [CoCp*(I)(2)](2) (Cp* = pentamethylcyclopentadienyl) affords the chelate complex …
The novel P-N ligand 1-((diphenylphosphaneyl)methyl)-1H-benzo-1,2,3-triazole (1), based on a benzotriazole scaffold, has been prepare …
Synthesis and reactivity of an iridium complex based on a tridentate aminophosphano ligand.
Palmese M, Pérez-Torrente JJ, Passarelli V. Palmese M, et al. Dalton Trans. 2022 May 10;51(18):7142-7153. doi: 10.1039/d2dt00794k. Dalton Trans. 2022. PMID: 35466986
The iridium(III) hydride compound [IrH{kappa(3)C,P,P'-(SiNP-H)}(CN(t)Bu)(2)][PF(6)] (1PF(6)) was obtained by reaction of [Ir(SiNP)(cod)][PF(6)] with CN(t)Bu as the result of the intramolecular oxidative addition of the SiCH(2)-H bond to iridium(I) [SiNP = Si( …
The iridium(III) hydride compound [IrH{kappa(3)C,P,P'-(SiNP-H)}(CN(t)Bu)(2)][PF(6)] (1PF(6)) was obtained by reaction o …
Mutations in MICAL-1cause autosomal-dominant lateral temporal epilepsy.
Dazzo E, Rehberg K, Michelucci R, Passarelli D, Boniver C, Vianello Dri V, Striano P, Striano S, Pasterkamp RJ, Nobile C. Dazzo E, et al. Ann Neurol. 2018 Mar;83(3):483-493. doi: 10.1002/ana.25167. Epub 2018 Mar 13. Ann Neurol. 2018. PMID: 29394500
RESULTS: We identified two ADLTE-causing variants in the MICAL-1 gene: a p.Gly150Ser substitution occurring in the enzymatically active monooxygenase (MO) domain and a p.Ala1065fs frameshift indel in the C-terminal domain, which inhibits the oxidoreductase ac …
RESULTS: We identified two ADLTE-causing variants in the MICAL-1 gene: a p.Gly150Ser substitution occurring in the enzymatically acti …
Serum albumin modified by carbamoylation impairs macrophage cholesterol efflux in diabetic kidney disease.
de Araújo Lira AL, de Fátima Mello Santana M, de Souza Pinto R, Minanni CA, Iborra RT, de Lima AMS, Correa-Giannella ML, Passarelli M, Queiroz MS. de Araújo Lira AL, et al. J Diabetes Complications. 2021 Sep;35(9):107969. doi: 10.1016/j.jdiacomp.2021.107969. Epub 2021 May 28. J Diabetes Complications. 2021. PMID: 34183248
RESULTS: Determination of CML, HCit, CBL in plasma, as total AGE and pentosidine in albumins, did not differ between groups; however, CBL in the isolated albumins was higher in the more advanced stages of CKD (p=0.0414). There was reduction in the (14)C-cholesterol …
RESULTS: Determination of CML, HCit, CBL in plasma, as total AGE and pentosidine in albumins, did not differ between groups; however, CBL in …
70 results