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Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice.
Tarantini S, Valcarcel-Ares MN, Toth P, Yabluchanskiy A, Tucsek Z, Kiss T, Hertelendy P, Kinter M, Ballabh P, Süle Z, Farkas E, Baur JA, Sinclair DA, Csiszar A, Ungvari Z. Tarantini S, et al. Among authors: hertelendy p. Redox Biol. 2019 Jun;24:101192. doi: 10.1016/j.redox.2019.101192. Epub 2019 Apr 10. Redox Biol. 2019. PMID: 31015147 Free PMC article.
Pharmacologically-induced neurovascular uncoupling is associated with cognitive impairment in mice.
Tarantini S, Hertelendy P, Tucsek Z, Valcarcel-Ares MN, Smith N, Menyhart A, Farkas E, Hodges EL, Towner R, Deak F, Sonntag WE, Csiszar A, Ungvari Z, Toth P. Tarantini S, et al. Among authors: hertelendy p. J Cereb Blood Flow Metab. 2015 Nov;35(11):1871-81. doi: 10.1038/jcbfm.2015.162. Epub 2015 Jul 15. J Cereb Blood Flow Metab. 2015. PMID: 26174328 Free PMC article.
Treatment with the mitochondrial-targeted antioxidant peptide SS-31 rescues neurovascular coupling responses and cerebrovascular endothelial function and improves cognition in aged mice.
Tarantini S, Valcarcel-Ares NM, Yabluchanskiy A, Fulop GA, Hertelendy P, Gautam T, Farkas E, Perz A, Rabinovitch PS, Sonntag WE, Csiszar A, Ungvari Z. Tarantini S, et al. Among authors: hertelendy p. Aging Cell. 2018 Apr;17(2):e12731. doi: 10.1111/acel.12731. Epub 2018 Feb 6. Aging Cell. 2018. PMID: 29405550 Free PMC article.
Nrf2 Deficiency Exacerbates Obesity-Induced Oxidative Stress, Neurovascular Dysfunction, Blood-Brain Barrier Disruption, Neuroinflammation, Amyloidogenic Gene Expression, and Cognitive Decline in Mice, Mimicking the Aging Phenotype.
Tarantini S, Valcarcel-Ares MN, Yabluchanskiy A, Tucsek Z, Hertelendy P, Kiss T, Gautam T, Zhang XA, Sonntag WE, de Cabo R, Farkas E, Elliott MH, Kinter MT, Deak F, Ungvari Z, Csiszar A. Tarantini S, et al. Among authors: hertelendy p. J Gerontol A Biol Sci Med Sci. 2018 Jun 14;73(7):853-863. doi: 10.1093/gerona/glx177. J Gerontol A Biol Sci Med Sci. 2018. PMID: 29905772 Free PMC article.
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