Impact of PET/CT Imaging with FDG in Locally Advanced Cervical Carcinoma-A Literature Review

Curr Oncol. 2024 Apr 29;31(5):2508-2526. doi: 10.3390/curroncol31050188.

Abstract

Positron emission tomography (PET) and computed tomography (CT) have evolved as a pivotal diagnostic modality in the field of oncology. With its increasing application in staging and ready availability, it becomes imperative for committed radiation oncologists to possess a complete analysis and understanding of integration of molecular imaging, which can be helpful for radiation planning, while also acknowledging its possible limitations and challenges. A significant obstacle lies in the synthesis and design of tumor-specific bmolecules for diagnosing and treating cancer. The utilization of radiation in medical biochemistry and biotechnology, encompassing diagnosis, therapy, and control of biological systems, is encapsulated under the umbrella term "nuclear medicine". Notably, the application of various radioisotopes in pharmaceutics has garnered significant attention, particularly in the realm of delivery systems for drugs, DNA, and imaging agents. The present article provides a comprehensive review of use of novel techniques PET and CT with major positron-emitting radiopharmaceuticals currently in progress or utilized in clinical practice with their integration into imaging and radiation therapy.

Keywords: FDG; PET; cervical cancer; computed tomography; diagnostics; follow up; oncology; radiopharmaceuticals; screening; treatment.

Publication types

  • Review

MeSH terms

  • Female
  • Fluorodeoxyglucose F18* / therapeutic use
  • Humans
  • Positron Emission Tomography Computed Tomography* / methods
  • Radiopharmaceuticals / therapeutic use
  • Uterine Cervical Neoplasms* / diagnostic imaging
  • Uterine Cervical Neoplasms* / therapy

Substances

  • Fluorodeoxyglucose F18
  • Radiopharmaceuticals

Grants and funding

This research received no external funding.