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Pluripotent stem cell therapy for retinal diseases.
Ahmed I, Johnston RJ Jr, Singh MS. Ahmed I, et al. Ann Transl Med. 2021 Aug;9(15):1279. doi: 10.21037/atm-20-4747. Ann Transl Med. 2021. PMID: 34532416 Free PMC article. Review.
As this field continues to evolve, additional technologies may enhance PSC-derived cell transplantation through gene-editing of autologous cells, transplantation of more complex cellular structures such as organoids, and monitoring of transplanted cells through novel imagi …
As this field continues to evolve, additional technologies may enhance PSC-derived cell transplantation through gene-editing of autologous c …
Novel approaches to liver disease diagnosis and modeling.
Oliveira AG, Fiorotto R. Oliveira AG, et al. Transl Gastroenterol Hepatol. 2021 Apr 5;6:19. doi: 10.21037/tgh-20-109. eCollection 2021. Transl Gastroenterol Hepatol. 2021. PMID: 33824923 Free PMC article. Review.
., genomic, proteomics, metabolomics) and computational tools for their analysis and integration, together with advances in modeling diseases using stem cell-based technology [i.e., induced pluripotent stem cells (iPSCs) and tissue organoids] represent a promising and powe …
., genomic, proteomics, metabolomics) and computational tools for their analysis and integration, together with advances in modeling disease …
Favorable tumor biology in locally advanced pancreatic cancer-beyond CA19-9.
Kinny-Köster B, Habib JR, Wolfgang CL, He J, Javed AA. Kinny-Köster B, et al. J Gastrointest Oncol. 2021 Oct;12(5):2484-2494. doi: 10.21037/jgo-20-426. J Gastrointest Oncol. 2021. PMID: 34790409 Free PMC article. Review.
Recent investigations on the use of circulating tumor DNA (ctDNA) and circulating tumor cells (CTCs) using liquid biopsies, as well as patient-derived organoids to characterize tumor biology have shown promise in achieving precise tumor biology-based patient stratification …
Recent investigations on the use of circulating tumor DNA (ctDNA) and circulating tumor cells (CTCs) using liquid biopsies, as well as patie …
Patient-derived cell line, xenograft and organoid models in lung cancer therapy.
Huo KG, D'Arcangelo E, Tsao MS. Huo KG, et al. Transl Lung Cancer Res. 2020 Oct;9(5):2214-2232. doi: 10.21037/tlcr-20-154. Transl Lung Cancer Res. 2020. PMID: 33209645 Free PMC article. Review.
Here, we discuss and compare different pre-clinical lung cancer models, including established cell lines, patient-derived cell lines, xenografts and organoids, summarize the methodology for generating these models, and review their relative advantages and limitations in di …
Here, we discuss and compare different pre-clinical lung cancer models, including established cell lines, patient-derived cell lines, xenogr …