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Page 1
Microheterogeneity of therapeutic monoclonal antibodies is governed by changes in the surface charge of the protein.
Biotechnol J. 2016 Dec;11(12):1617-1627. doi: 10.1002/biot.201600504. Epub 2016 Nov 22.
Biotechnol J. 2016.
PMID: 27753240
Immune Response and Outcome of High-Risk Neuroblastoma Patients Immunized with Anti-Idiotypic Antibody Ganglidiomab: Results from Compassionate-Use Treatments.
Klingel L, Siebert N, Troschke-Meurer S, Zumpe M, Ehlert K, Huber S, Loibner H, Mutschlechner O, Lode HN.
Klingel L, et al. Among authors: mutschlechner o.
Cancers (Basel). 2022 Nov 25;14(23):5802. doi: 10.3390/cancers14235802.
Cancers (Basel). 2022.
PMID: 36497290
Free PMC article.
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Charge heterogeneity: Basic antibody charge variants with increased binding to Fc receptors.
Hintersteiner B, Lingg N, Zhang P, Woen S, Hoi KM, Stranner S, Wiederkum S, Mutschlechner O, Schuster M, Loibner H, Jungbauer A.
Hintersteiner B, et al. Among authors: mutschlechner o.
MAbs. 2016 Nov/Dec;8(8):1548-1560. doi: 10.1080/19420862.2016.1225642. Epub 2016 Aug 25.
MAbs. 2016.
PMID: 27559765
Free PMC article.
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Low CD4⁺/CD25⁺/CD127⁻ regulatory T cell- and high INF-γ levels are associated with improved survival of neuroblastoma patients treated with long-term infusion of ch14.18/CHO combined with interleukin-2.
Troschke-Meurer S, Siebert N, Marx M, Zumpe M, Ehlert K, Mutschlechner O, Loibner H, Ladenstein R, Lode HN.
Troschke-Meurer S, et al. Among authors: mutschlechner o.
Oncoimmunology. 2019 Sep 8;8(12):1661194. doi: 10.1080/2162402X.2019.1661194. eCollection 2019.
Oncoimmunology. 2019.
PMID: 31741754
Free PMC article.
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