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Page 1
Discovery of Antitrypanosomal Indolylacetamides by a Deconstruction-Optimization Strategy Applied to Paullones.
ChemMedChem. 2023 May 16;18(10):e202300036. doi: 10.1002/cmdc.202300036. Epub 2023 Mar 28.
ChemMedChem. 2023.
PMID: 36847711
The indole motif is essential for the antitrypanosomal activity of N5-substituted paullones.
Ihnatenko I, Müller MJ, Orban OCF, Lindhof JC, Benítez D, Ortíz C, Dibello E, Seidl LL, Comini MA, Kunick C.
Ihnatenko I, et al. Among authors: orban ocf.
PLoS One. 2023 Nov 30;18(11):e0292946. doi: 10.1371/journal.pone.0292946. eCollection 2023.
PLoS One. 2023.
PMID: 38032881
Free PMC article.
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Mechanistic and biological characterisation of novel N5-substituted paullones targeting the biosynthesis of trypanothione in Leishmania.
Medeiros A, Benítez D, Korn RS, Ferreira VC, Barrera E, Carrión F, Pritsch O, Pantano S, Kunick C, de Oliveira CI, Orban OCF, Comini MA.
Medeiros A, et al. Among authors: orban ocf.
J Enzyme Inhib Med Chem. 2020 Dec;35(1):1345-1358. doi: 10.1080/14756366.2020.1780227.
J Enzyme Inhib Med Chem. 2020.
PMID: 32588679
Free PMC article.
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Trypanothione synthetase confers growth, survival advantage and resistance to anti-protozoal drugs in Trypanosoma cruzi.
Mesías AC, Sasoni N, Arias DG, Pérez Brandán C, Orban OCF, Kunick C, Robello C, Comini MA, Garg NJ, Zago MP.
Mesías AC, et al. Among authors: orban ocf.
Free Radic Biol Med. 2019 Jan;130:23-34. doi: 10.1016/j.freeradbiomed.2018.10.436. Epub 2018 Oct 23.
Free Radic Biol Med. 2019.
PMID: 30359758
Free PMC article.
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5-Substituted 3-chlorokenpaullone derivatives are potent inhibitors of Trypanosoma brucei bloodstream forms.
Orban OC, Korn RS, Benítez D, Medeiros A, Preu L, Loaëc N, Meijer L, Koch O, Comini MA, Kunick C.
Orban OC, et al.
Bioorg Med Chem. 2016 Aug 15;24(16):3790-800. doi: 10.1016/j.bmc.2016.06.023. Epub 2016 Jun 13.
Bioorg Med Chem. 2016.
PMID: 27349574
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