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The following term was not found in PubMed: Arifin-Wong
Page 1
Uncompetitive, adduct-forming SARM1 inhibitors are neuroprotective in preclinical models of nerve injury and disease.
Bratkowski M, Burdett TC, Danao J, Wang X, Mathur P, Gu W, Beckstead JA, Talreja S, Yang YS, Danko G, Park JH, Walton M, Brown SP, Tegley CM, Joseph PRB, Reynolds CH, Sambashivan S. Bratkowski M, et al. Neuron. 2022 Nov 16;110(22):3711-3726.e16. doi: 10.1016/j.neuron.2022.08.017. Epub 2022 Sep 9. Neuron. 2022. PMID: 36087583 Free article.
Mechanisms of helicase activated DNA end resection in bacteria.
Xu Y, Xu L, Qin C, Wang L, Guo J, Hua Y, Zhao Y. Xu Y, et al. Structure. 2022 Sep 1;30(9):1298-1306.e3. doi: 10.1016/j.str.2022.06.005. Epub 2022 Jul 15. Structure. 2022. PMID: 35841886 Free article.
Here, we report the cryo-electron microscopy structure of a bacterial HerA-NurA complex from Deinococcus radiodurans. The structure reveals a barrel-like hexameric HerA and a distinctive NurA dimer subcomplex, which has a unique extended N-terminal region (ENR) invo …
Here, we report the cryo-electron microscopy structure of a bacterial HerA-NurA complex from Deinococcus radiodurans. The structure r …
NURA: A curated dataset of nuclear receptor modulators.
Valsecchi C, Grisoni F, Motta S, Bonati L, Ballabio D. Valsecchi C, et al. Toxicol Appl Pharmacol. 2020 Nov 15;407:115244. doi: 10.1016/j.taap.2020.115244. Epub 2020 Sep 19. Toxicol Appl Pharmacol. 2020. PMID: 32961130
To the best of our knowledge, NURA dataset is the most exhaustive collection of small molecules annotated for their modulation of the chosen nuclear receptors. NURA dataset is intended to support decision-making in pharmacology and toxicology, as well as to contribu …
To the best of our knowledge, NURA dataset is the most exhaustive collection of small molecules annotated for their modulation of the …
Molecular architecture of the HerA-NurA DNA double-strand break resection complex.
Byrne RT, Schuller JM, Unverdorben P, Förster F, Hopfner KP. Byrne RT, et al. FEBS Lett. 2014 Dec 20;588(24):4637-44. doi: 10.1016/j.febslet.2014.10.035. Epub 2014 Nov 11. FEBS Lett. 2014. PMID: 25447518 Free article.
HerA forms an ASCE hexamer that tightly interacts with a NurA dimer, with each NurA protomer binding three adjacent HerA HAS domains. ...The structure suggests that HerA is a dsDNA translocase that feeds DNA into the NurA nuclease sites....
HerA forms an ASCE hexamer that tightly interacts with a NurA dimer, with each NurA protomer binding three adjacent HerA HAS d …
Structural and DNA end resection study of the bacterial NurA-HerA complex.
Yang J, Sun Y, Wang Y, Hao W, Cheng K. Yang J, et al. BMC Biol. 2023 Feb 24;21(1):42. doi: 10.1186/s12915-023-01542-0. BMC Biol. 2023. PMID: 36829173 Free PMC article.
A NurA-HerA complex is known to mediate DSB DNA end resection, leading to formation of a free 3' end used to search for the homologous sequence. ...Some bacteria also possess homologs of NurA and HerA; however, the bacterial type of this complex, as well as the deta …
A NurA-HerA complex is known to mediate DSB DNA end resection, leading to formation of a free 3' end used to search for the homologou …
Crystal structure of the NurA-dAMP-Mn2+ complex.
Chae J, Kim YC, Cho Y. Chae J, et al. Nucleic Acids Res. 2012 Mar;40(5):2258-70. doi: 10.1093/nar/gkr999. Epub 2011 Nov 7. Nucleic Acids Res. 2012. PMID: 22064858 Free PMC article.
We have determined the crystal structures of apo- and dAMP-Mn(2)(+)-bound NurA from Pyrococcus furiousus (Pf NurA) to provide the basis for its cleavage mechanism. ...The 3' OH group of the ribose ring is directed toward the channel entrance, explaining the 5'-3' nu …
We have determined the crystal structures of apo- and dAMP-Mn(2)(+)-bound NurA from Pyrococcus furiousus (Pf NurA) to provide …
Parkinson's Progression Markers Initiative: A Milestone-Based Strategy to Monitor Parkinson's Disease Progression.
Brumm MC, Siderowf A, Simuni T, Burghardt E, Choi SH, Caspell-Garcia C, Chahine LM, Mollenhauer B, Foroud T, Galasko D, Merchant K, Arnedo V, Hutten SJ, O'Grady AN, Poston KL, Tanner CM, Weintraub D, Kieburtz K, Marek K, Coffey CS; Parkinson’s Progression Markers Initiative. Brumm MC, et al. J Parkinsons Dis. 2023;13(6):899-916. doi: 10.3233/JPD-223433. J Parkinsons Dis. 2023. PMID: 37458046 Free PMC article.
Biochemical and Functional Characterization of the NurA-HerA Complex from Deinococcus radiodurans.
Cheng K, Chen X, Xu G, Wang L, Xu H, Yang S, Zhao Y, Hua Y. Cheng K, et al. J Bacteriol. 2015 Jun 15;197(12):2048-61. doi: 10.1128/JB.00018-15. Epub 2015 Apr 13. J Bacteriol. 2015. PMID: 25868646 Free PMC article.
In archaea, the NurA nuclease and HerA ATPase/helicase, together with the Mre11-Rad50 complex, function in 3' single-stranded DNA (ssDNA) end processing during homologous recombination (HR). However, bacterial homologs of NurA and HerA have not been characterized. F …
In archaea, the NurA nuclease and HerA ATPase/helicase, together with the Mre11-Rad50 complex, function in 3' single-stranded DNA (ss …
132 results